Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765082 | 0.91 | PKM (0.43) | PLA2G2AMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5762337 | 0.89 | MAPT (0.41) | PDE1BPLA2G2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5764801 | 0.86 | AURKA (0.42) | MAPTSMN1; SMN2KDM4EALDH1A1HTT | |
| SCHEMBL5765021 | 0.84 | GAA (0.38) | PTGDR2PLA2G2AMAPTKMT2AMEN1 | |
| SCHEMBL4757197 | 0.79 | MTNR1B (0.52) | PLA2G2AMAPTALDH1A1PLA2G1BTP53 | |
| SCHEMBL5762171 | 0.78 | PLA2G1B (0.42) | PLA2G2AMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5763144 | 0.78 | PLA2G2A (0.57) | PLA2G2APLA2G1B | |
| SCHEMBL5766775 | 0.77 | PLA2G2A (0.40) | PLA2G2AMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5764508 | 0.75 | PPARG (0.40) | PLA2G2AMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL5764178 | 0.73 | MAPT (0.40) | PDE1BPLA2G2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091738-B1 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6384041-B1 | ANTIINFLAMMATORY AGENT, TREATMENT OF SHOCK AND ENZYME INHIBITORS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |