Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 11/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KIF5B | P33176 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | PDE6D | O43924 | 2/20 | 0.34 |
| ▸ | PDE6A | P16499 | 2/20 | 0.34 |
| ▸ | PDE6G | P18545 | 2/20 | 0.34 |
| ▸ | PDE6B | P35913 | 2/20 | 0.34 |
| ▸ | PDE6C | P51160 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20521814 | 0.82 | CYP3A4 (0.44) | MAPTNPC1POLBGAAKMT2A | |
| SCHEMBL6587566 | 0.81 | KMT2A (0.43) | MAPTNPC1GAAKDROPRK1 | |
| SCHEMBL9830239 | 0.81 | NQO2 (0.46) | MAPTNPC1POLBGAADHFR | |
| SCHEMBL4244668 | 0.81 | CRHR1 (0.41) | MAPTNPC1PDE2APDE10ADHFR | |
| SCHEMBL30615098 | 0.79 | ADORA2A (0.35) | PDE2APDE10ARETKIF5BKDR | |
| SCHEMBL29091670 | 0.79 | ADORA2A (0.35) | PDE2APDE10ARETKIF5BKDR | |
| SCHEMBL20680327 | 0.77 | LMNA (0.38) | MAPTGAAOPRK1KMT2A | |
| SCHEMBL21996308 | 0.76 | ADORA2A (0.40) | NPC1KDRADORA2A | |
| SCHEMBL1564292 | 0.75 | GAA (0.54) | MAPTNPC1POLBGAAPDE10A | |
| SCHEMBL13738009 | 0.74 | CCR1 (0.46) | MAPTPDE2APDE10APDE5APDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023773-A1 | COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS | PAINCEPTOR PHARMA CORPORATION (CA) | 2009-01-22 | — | — | US | disclosed |
| US-20090023773-A1 | COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS | PAINCEPTOR PHARMA CORPORATION (CA) | 2009-01-22 | — | — | US | disclosed |
| WO-2009000085-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES USEFUL AS MODULATORS OF GATED ION CHANNELS | PAINCEPTOR PHARMA CORPORATION (CA) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000085-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES USEFUL AS MODULATORS OF GATED ION CHANNELS | PAINCEPTOR PHARMA CORPORATION (CA) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023773-A1 | COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS | TRPV1, TRPV2, TRPA1 | MAPT 2142/4885NPC1 1874/4885POLB 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.