Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757884 | 0.84 | ALDH1A1 (0.54) | MAPTALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL4756925 | 0.81 | KCNH2 (0.41) | MAPTPKMALDH1A1TSHRGAA | |
| SCHEMBL4755716 | 0.77 | PDE4B (0.39) | MAPTPKMALDH1A1TSHRGAA | |
| SCHEMBL4755073 | 0.76 | FDFT1 (0.39) | MAPTPKMALDH1A1SMN1; SMN2FDFT1 | |
| SCHEMBL4755037 | 0.76 | CA12 (0.42) | ALDH1A1HTTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL4756906 | 0.71 | SLC6A2 (0.43) | — | |
| SCHEMBL4437609 | 0.70 | ALDH1A1 (0.48) | MAPTTLR9TLR8TLR7ALDH1A1 | |
| SCHEMBL2950876 | 0.69 | MAPT (0.61) | MAPTALDH1A1TSHRGAAHTT | |
| SCHEMBL8902326 | 0.69 | MAPT (0.61) | MAPTALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL7589274 | 0.69 | CA12 (0.62) | KDM4ENPSR1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |