Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651339 | 0.62 | HDAC3 (0.52) | KMT2AALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL273348 | 0.61 | KDM4E (0.51) | TP53KMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL455438 | 0.59 | KMT2A (0.53) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL28779007 | 0.59 | L3MBTL1 (0.42) | KMT2AALDH1A1SRCSMN1; SMN2MEN1 | |
| SCHEMBL514386 | 0.58 | SMN1; SMN2 (0.53) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL4760700 | 0.58 | KDM4E (0.47) | KMT2AALDH1A1MEN1LMNARAB9A | |
| Hydrochloric Acid SCHEMBL6788749 | 0.57 | KMT2A (0.52) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL5648913 | 0.57 | LIPE (0.45) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL23064984 | 0.57 | RAB9A (0.54) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL491229 | 0.57 | RAB9A (0.54) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963331-A1 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007070796-A1 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |