SCHEMBL476252

SCHEMBL476252

Nc1ccc(Oc2ccccc2C(F)(F)F)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NCOA1 Q15788 1/20 0.51
NCOA3 Q9Y6Q9 1/20 0.51
LTA4H P09960 1/20 0.51
PTGS2 P35354 1/20 0.51
MAOA P21397 2/20 0.50
ALDH1A1 P00352 4/20 0.46
CYP3A4 P08684 1/20 0.46
TSHR P16473 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
AR P10275 4/20 0.43
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
MAPT P10636 3/20 0.42
MITF O75030 1/20 0.42
GAA P10253 1/20 0.42
GFER P55789 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NLRP1 Q9C000 1/20 0.42
NOD2 Q9HC29 1/20 0.42
NPC1 O15118 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29553142 1.00 NCOA1 (0.51) NCOA1NCOA3LTA4HPTGS2MAOA
SCHEMBL11521654 0.90 LTA4H (0.58) LTA4HPTGS2ALDH1A1ARLPAR1
SCHEMBL17783722 0.88 GAA (0.54) NCOA1NCOA3LTA4HPTGS2MAOA
SCHEMBL721404 0.86 NCOA1 (0.49) NCOA1NCOA3LTA4HPTGS2MAOA
SCHEMBL17783721 0.85 LTA4H (0.41) NCOA1NCOA3LTA4HPTGS2MAOA
SCHEMBL1676646 0.84 LTA4H (0.53) LTA4HPTGS2TSHRARKMT2A
SCHEMBL14677727 0.83 LTA4H (0.52) LTA4HPTGS2ALDH1A1TSHRAR
SCHEMBL5583602 0.83 NCOA1 (0.46) NCOA1NCOA3LTA4HPTGS2MAOA
SCHEMBL8761225 0.82 NCOA1 (0.40) NCOA1NCOA3LTA4HPTGS2MAOA
SCHEMBL8762110 0.82 NCOA1 (0.40) NCOA1NCOA3LTA4HPTGS2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2024-05-30 US disclosed
EP-4288412-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME Rappta Therapeutics Oy (FI) 2023-12-13 EP disclosed
US-11286359-B2 Prepreg and carbon fiber-reinforced composite material TORAY INDUSTRIES, INC. (JP) 2022-03-29 US disclosed
US-11111345-B2 Prepreg and carbon fiber-reinforced composite material TORAY INDUSTRIES, INC. (JP) 2021-09-07 US disclosed
CN-110191915-B Prepreg, method for producing same, and slit tape prepreg 东丽株式会社 2021-07-23 CN disclosed
EP-3800285-A1 SIZING-AGENT-COATED CARBON FIBRE BUNDLE, CARBON-FIBRE-BUNDLE PRODUCTION METHOD, AND PREPREG Toray Industries, Inc. (JP) 2021-04-07 EP disclosed
CN-112313078-A Prepreg, method for producing prepreg, slit tape prepreg, and carbon fiber-reinforced composite material 东丽株式会社 2021-02-02 CN disclosed
WO-2019141980-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2019-07-25 WO disclosed
US-10184034-B2 Carbon fiber forming raw material, formed material, and carbon fiber-reinforced composite material TORAY INDUSTRIES, INC. (JP) 2019-01-22 US disclosed
US-10138593-B2 Sizing agent-coated carbon fibers, process for producing sizing agent-coated carbon fibers, prepreg, and carbon fiber reinforced composite material TORAY INDUSTRIES, INC. (JP) 2018-11-27 US disclosed
US-8263216-B2 Epoxy resin composition for fiber-reinforced composite material, prepreg, and fiber-reinforced composite material TORAY INDUSTRIES, INC. (JP) 2012-09-11 US disclosed
US-20120035299-A1 EPOXY RESIN COMPOSITION FOR FIBER-REINFORCED COMPOSITE MATERIAL, PREPREG, AND FIBER-REINFORCED COMPOSITE MATERIAL TORAY INDUSTRIES, INC. (JP) 2012-02-09 US disclosed
EP-2412742-A1 EPOXY RESIN COMPOSITION FOR FIBER-REINFORCED COMPOSITE MATERIAL, PREPREG, AND FIBER-REINFORCED COMPOSITE MATERIAL Toray Industries, Inc. (JP) 2012-02-01 EP disclosed
EP-2341092-A1 EPOXY COMPOUND AND MANUFACTURING METHOD THEREOF Toray Fine Chemicals Co., Ltd. (JP) 2011-07-06 EP disclosed
US-20110040111-A1 EPOXY COMPOUND AND MANUFACTURING METHOD THEREOF TORAY FINE CHEMICALS CO., LTD. (JP) 2011-02-17 US disclosed
US-7595317-B2 Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases BRISTOL-MYERS SQUIBB COMPANY (US) 2009-09-29 US disclosed
US-7294624-B2 Osteoporosis; antiarthritic agents BRISTOL MYERS SQUIBB COMPANY (US) 2007-11-13 US disclosed
US-20070167451-A1 BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-alpha CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES DUAN JINGWU 2007-07-19 US disclosed
US-6953807-B2 4-substituted-picolinic acid amide derivatives useful as fungicides BAYER CROPSCIENCE S.A. (FR) 2005-10-11 US disclosed
WO-2003053941-A2 BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-ALPHA CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES BRISTOL-MYERS SQUIBB COMPANY (US) 2003-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110040111-A1 EPOXY COMPOUND AND MANUFACTURING METHOD THEREOF CYP2E1, CYP4A11, CYP1A1 NCOA1 186/4885NCOA3 403/4885LTA4H 154/4885
US-20070167451-A1 BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-alpha CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES TNF, MMP9, MMP3 NCOA1 3470/4885NCOA3 3719/4885LTA4H 615/4885
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME PPM1A, PPP2CA, PPP3CA NCOA1 1434/4885NCOA3 1627/4885LTA4H 2459/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.