Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ASPH | Q12797 | 3/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.40 |
| ▸ | KDM5A | P29375 | 4/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | GABRE | P78334 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30963968 | 0.84 | KDM4E (0.39) | NAPRTKDM4EASPHKDM8L3MBTL1 | |
| SCHEMBL19857473 | 0.80 | KDM4E (0.55) | KDM4EASPHKDM8KDM5BKDM5A | |
| SCHEMBL15527710 | 0.80 | GABRP (0.46) | KDM4EASPHKDM8KDM5BKDM5A | |
| SCHEMBL6931488 | 0.79 | NOS2 (0.55) | NAPRTKDM4EASPHKDM8KDM5B | |
| SCHEMBL31402348 | 0.79 | KDM5B (0.41) | KDM4EASPHKDM8KDM5BKDM5A | |
| SCHEMBL4954467 | 0.79 | LMNA (0.50) | KDM4EASPHKDM8KDM5BKDM5A | |
| SCHEMBL28260878 | 0.76 | KDM4E (0.39) | KDM4EASPHKDM8KDM5BKDM5A | |
| SCHEMBL14836840 | 0.76 | GABRP (0.39) | KDM4EASPHKDM8KDM5BKDM5A | |
| SCHEMBL16837130 | 0.76 | NAPRT (0.55) | NAPRTKDM4EASPHKDM8KDM5B | |
| SCHEMBL2027279 | 0.76 | NAPRT (0.55) | NAPRTKDM4EASPHKDM8KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312211-A1 | Antibacterial Pyrrolopyridines, Pyrrolopyrimidines and Pyrroloazepines-154 | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| EP-1991545-A2 | ANTIBACTERIAL PYRROLOPYRIDINES, PYRROLOPYRIMIDINES, AND PYRROLOAZEPINES | AstraZeneca AB (SE) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007071965-A2 | ANTIBACTERIAL PYRROLOPYRIDINES, PYRROLOPYRIMIDINES, AND PYRROLOAZEPINES | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312211-A1 | Antibacterial Pyrrolopyridines, Pyrrolopyrimidines and Pyrroloazepines-154 | SDHA, QDPR, PNKP | NAPRT 664/4885KDM4E 1269/4885ASPH 2057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.