Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | DTYMK | P23919 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226349 | 0.90 | GRM5 (0.43) | POLBGRM5PDE10AGPR119USP30 | |
| SCHEMBL5226358 | 0.90 | GRM5 (0.43) | POLBGRM5PDE10AGPR119USP30 | |
| SCHEMBL31163752 | 0.90 | GRM5 (0.43) | POLBGRM5PDE10AGPR119USP30 | |
| SCHEMBL5226353 | 0.90 | GRM5 (0.43) | POLBGRM5PDE10AGPR119USP30 | |
| SCHEMBL4479936 | 0.85 | LMNA (0.42) | ALDH1A1KDM4EGPR119USP30LMNA | |
| SCHEMBL5245529 | 0.83 | MEN1 (0.39) | ALDH1A1KDM4EGRM5GPR119DTYMK | |
| SCHEMBL5245532 | 0.83 | MEN1 (0.39) | ALDH1A1KDM4EGRM5GPR119DTYMK | |
| SCHEMBL5245539 | 0.83 | MEN1 (0.39) | ALDH1A1KDM4EGRM5GPR119DTYMK | |
| SCHEMBL6414267 | 0.82 | CYP11B2 (0.36) | ALDH1A1POLBGPR119USP30LMNA | |
| SCHEMBL2350223 | 0.80 | ADORA1 (0.42) | ALDH1A1KDM4EGRM5USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989993-B1 | TARTRATE SALT OF A SUBSTITUTED DIPEPTIDE AS GROWTH HORMONE SECRETAGOGUE | PFIZER PROD INC (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1000085-B1 | TREATMENT OF INSULIN RESISTANCE WITH GROWTH HORMONE SECRETAGOGUES | PFIZER PROD INC (US) | 2005-09-28 | — | — | EP | disclosed |
| US-6867202-B1 | Increasing level of endogenous growth hormone using growth hormone secretagogue such as 2-amino-N-(2-(3a-benzyl-2-methy-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo-(4,3 -c)pyridin-5-yl)-1-benzyloxymethyl-2-oxo-ethyl)-isobutyramide tartarate salt | PFIZER INC. (US) | 2005-03-15 | — | — | US | disclosed |
| US-6673929-B2 | Process for preparing growth hormone secretagogues | PFIZER INC. | 2004-01-06 | — | — | US | disclosed |
| US-6630487-B2 | Treatment of insulin resistance with growth hormone secretagogues | PFIZER INC. | 2003-10-07 | — | — | US | disclosed |
| US-20030158414-A1 | Process for preparing growth hormone secretagogues | RAQUALIA PHARMA INC. (JP) | 2003-08-21 | — | — | US | disclosed |
| US-20030100561-A1 | Administering 2-amino-N-(1-(3a-benzyl-2-methyl-3-oxo-2,3,3a, 4,6,7-hexahydro-pyrazolo(4,3-c)pyridine-5-carbonyl)-4-phenyl-butyl) -isobutyramide for treating congestive heart failure, obesity | CARPINO PHILIP ALBERT (US) | 2003-05-29 | — | — | US | disclosed |
| US-6541634-B2 | Reacting a pyrazolo(4,3-a)pyridine compound with amine | PFIZER INC. | 2003-04-01 | — | — | US | disclosed |
| US-6448263-B1 | SYNTHESIS ROUTES FOR SUCH AS 2-AMINO-N-(2-(3A-(R)-BENZYL-2-METHYL-3-OXO-2,3,3A,4,6,7-HEXAHYDRO-PYRAZOLO -(4,3-C) PYRIDIN-5-YL)-1-(R)-BENZYLOXYMETHYL-2-OXO-ETHYL)-ISOBUTYRAMIDE L-TARTARIC ACID SALT | PFIZER INC. | 2002-09-10 | — | — | US | disclosed |
| US-20020002283-A1 | Process for preparing growth hormone secretagogues | RAQUALIA PHARMA INC. (JP) | 2002-01-03 | — | — | US | disclosed |
| US-6248717-B1 | TREATMENT OF OSTEOPOROSIS, CARDIOTONIC AGENTS, ANTIAGING AGENTS, WOUND HEALING AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100561-A1 | Administering 2-amino-N-(1-(3a-benzyl-2-methyl-3-oxo-2,3,3a, 4,6,7-hexahydro-pyrazolo(4,3-c)pyridine-5-carbonyl)-4-phenyl-butyl) -isobutyramide for treating congestive heart failure, obesity | GIPR, GHSR, GPR119 | ALDH1A1 1938/4885POLB 4104/4885KDM4E 1856/4885 |
| US-20020002283-A1 | Process for preparing growth hormone secretagogues | GHRHR, GHSR, PRLHR | ALDH1A1 3923/4885POLB 3752/4885KDM4E 3310/4885 |
| US-20030158414-A1 | Process for preparing growth hormone secretagogues | GHRHR, GHSR, PRLHR | ALDH1A1 3923/4885POLB 3752/4885KDM4E 3310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.