Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776063 | 0.86 | NQO1 (0.43) | FGFR1CCNT1CDK4CCND1CDK9 | |
| SCHEMBL2788133 | 0.84 | CHKA (0.51) | CHKACCNT1CDK9WEE1GRIN1 | |
| SCHEMBL2788132 | 0.84 | CHKA (0.51) | CHKACCNT1CDK9WEE1GRIN1 | |
| SCHEMBL4774422 | 0.81 | CYP2C9 (0.36) | MAPT | |
| SCHEMBL4770645 | 0.74 | NEK2 (0.39) | CCNT1CDK9MAPTPDGFRBPDGFRA | |
| SCHEMBL2787956 | 0.71 | EGFR (0.52) | CCNT1CDK9MAPK1TNIK | |
| SCHEMBL2787952 | 0.71 | EGFR (0.52) | CCNT1CDK9MAPK1TNIK | |
| SCHEMBL4765880 | 0.70 | ROCK1 (0.43) | CCNT1CDK9CDK6MAPK1JAK3 | |
| SCHEMBL4775747 | 0.69 | GPR84 (0.38) | — | |
| SCHEMBL4768194 | 0.69 | BACE1 (0.36) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |