Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10150321 | 0.84 | SLC1A1 (0.50) | KEAP1TRPA1FFAR1 | |
| SCHEMBL30672191 | 0.83 | ALDH1A1 (0.55) | KEAP1TRPA1FFAR1ALDH1A1HDAC2 | |
| SCHEMBL6121990 | 0.83 | CYP1A2 (0.47) | KEAP1TRPA1CYP1A2SLC15A1ALPI | |
| SCHEMBL5599125 | 0.82 | KEAP1 (0.63) | KEAP1TRPA1FFAR1ALDH1A1TRPV1 | |
| SCHEMBL28005839 | 0.81 | TRPA1 (0.54) | KEAP1TRPA1FFAR1ALDH1A1TRPV1 | |
| SCHEMBL7581741 | 0.81 | KEAP1 (0.61) | KEAP1TRPA1FFAR1ALDH1A1TRPV1 | |
| SCHEMBL454095 | 0.80 | CES2 (0.52) | TRPA1HDAC8HDAC6CYP1A2SLC15A1 | |
| SCHEMBL28186887 | 0.80 | CYP1A2 (0.52) | KEAP1TRPA1CYP1A2SLC15A1ALPI | |
| SCHEMBL8507342 | 0.79 | KEAP1 (0.59) | KEAP1TRPA1FFAR1ALDH1A1TRPV1 | |
| SCHEMBL7270550 | 0.79 | KEAP1 (0.59) | KEAP1TRPA1FFAR1ALDH1A1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081910-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |