Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | FES | P07332 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4775257 | 0.94 | ROCK2 (0.44) | ROCK2ROCK1PLK4AURKAMAPK13 | |
| SCHEMBL4774628 | 0.79 | TMPRSS2 (0.61) | HRH3NPC1RAB9ATP53GAA | |
| SCHEMBL4770901 | 0.79 | HRH3 (0.56) | CHRNA7HRH3CYP2D6NPC1RAB9A | |
| SCHEMBL4768583 | 0.78 | TMPRSS2 (0.62) | NPC1RAB9ATP53GAANFKB1 | |
| SCHEMBL118485 | 0.78 | ROCK2 (0.46) | ROCK2CHRNA7HRH3CYP2D6TP53 | |
| SCHEMBL4770555 | 0.78 | NPC1 (0.51) | HRH3NPC1RAB9ATP53GAA | |
| SCHEMBL4767967 | 0.78 | HRH3 (0.48) | AURKAFLT1KDRHRH3NPC1 | |
| SCHEMBL4771157 | 0.77 | KMT2A (0.56) | HRH3NPC1RAB9ATP53HTT | |
| SCHEMBL4794145 | 0.77 | MAPT (0.53) | NTRK3NTRK2CLK4HRH3NPC1 | |
| SCHEMBL4774483 | 0.77 | SLC2A1 (0.52) | CHRNA7HRH3NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |