Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | MAOA | P21397 | 3/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.70 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA7 | P43166 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.62 |
| ▸ | ALPL | P05186 | 5/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALPI | P09923 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9463878 | 0.85 | ALDH1A1 (1.00) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL5321909 | 0.83 | KDM4E (0.72) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL11227397 | 0.83 | HSD17B10 (0.72) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL11432556 | 0.83 | MAOA (1.00) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL15984891 | 0.83 | MCL1 (1.00) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL4096663 | 0.82 | MAOA (0.59) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL11227296 | 0.82 | MCL1 (0.68) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL18232224 | 0.81 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL8876358 | 0.80 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| Trimethylammonium SCHEMBL9481220 | 0.80 | ALDH1A1 (0.88) | KDM4EALDH1A1HSD17B10TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080009544-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2008-01-10 | — | — | US | claimed |
| EP-2001463-B1 | A PHARMACEUTICAL COMPOSITION USEFUL AS ACETYL CHOLINESTERASE INHIBITORS | COUNCIL SCIENT IND RES (IN) | 2013-07-03 | — | — | EP | disclosed |
| US-20120277297-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-11-01 | — | — | US | disclosed |
| US-8188143-B2 | Pharmaceutical composition useful as acetylcholinesterase inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-05-29 | — | — | US | disclosed |
| EP-2001463-A1 | A PHARMACEUTICAL COMPOSITION USEFUL AS ACETYL CHOLINESTERASE INHIBITORS | Council of Scientific and Industrial Research (IN) | 2008-12-17 | — | — | EP | disclosed |
| US-20080009544-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2008-01-10 | — | — | US | disclosed |
| WO-2007107846-A1 | A PHARMACEUTICAL COMPOSITION USEFUL AS ACETYL CHOLINESTERASE INHIBITORS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009544-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | ACHE, BCHE, CHRNB1 | KDM4E 1482/4885ALDH1A1 1025/4885HSD17B10 457/4885 |
| US-20120277297-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | ACHE, BCHE, CYP3A7 | KDM4E 1461/4885ALDH1A1 547/4885HSD17B10 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.