Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16905417 | 0.67 | KDM4E (0.43) | DRD2PDK2PIK3CDPIK3CAPI4KA | |
| SCHEMBL4024459 | 0.65 | CYP11B1 (0.51) | PDK2PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL23351094 | 0.65 | CYP11B1 (0.47) | PDK2PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL13291983 | 0.65 | FAAH (0.44) | DRD2PDK2PIK3CDPIK3CAPI4KA | |
| SCHEMBL28665803 | 0.65 | FAAH (0.44) | DRD2PDK2PIK3CDPIK3CAPI4KA | |
| SCHEMBL12891743 | 0.65 | DRD2 (0.41) | DRD2PDK2PIK3CDPIK3CAPI4KA | |
| SCHEMBL26820010 | 0.65 | DRD2 (0.41) | DRD2PDK2PIK3CDPIK3CAPI4KA | |
| SCHEMBL12891748 | 0.65 | DRD2 (0.41) | DRD2PDK2PIK3CDPIK3CAPI4KA | |
| SCHEMBL4025451 | 0.64 | CYP11B1 (0.50) | PDK2PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL21557598 | 0.64 | HTR1A (0.47) | PDK2PIK3CDPIK3CAPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979353-A2 | FUSED HETEROBICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007084667-A2 | FUSED HETEROBICYCLIC KINASE INHIBITORS | OSI PHARMACEUTICAL, INC. (US) | 2007-07-26 | — | — | WO | disclosed |