Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | EDNRA | P25101 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | USP9X | Q93008 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1599758 | 0.91 | CYP3A4 (0.54) | MAPK1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL27675641 | 0.81 | HSD17B10 (0.46) | MAPK1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4816680 | 0.80 | KMT2A (0.63) | CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29180144 | 0.80 | SMAD3 (0.50) | MAPK1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4824905 | 0.80 | KMT2A (0.52) | MAPK1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7987319 | 0.79 | MAPK1 (0.50) | MAPK1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL14554563 | 0.79 | MAPK1 (0.51) | MAPK1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4825484 | 0.79 | PTGS1 (0.58) | MAPK1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7898797 | 0.79 | CYP3A4 (0.54) | MAPK1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL18626121 | 0.79 | CYP3A4 (0.54) | MAPK1CYP3A4CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726458-B1 | SYNTHESIS OF CLEISTANTHIN A AND DERIVATIVES THEREOF | GODAVARI BIOREFINERIES LTD (IN) | 2017-01-04 | — | — | EP | disclosed |
| US-8957230-B2 | Synthesis of cleistanthin A and derivatives thereof | GODAVARI BIOREFINERIES LIMITED (IN) | 2015-02-17 | — | — | US | disclosed |
| EP-2726458-A2 | SYNTHESIS OF CLEISTANTHIN A AN DERIVATIVES THEREOF | Godavari Biorefineries Ltd. (IN) | 2014-05-07 | — | — | EP | disclosed |
| US-8563786-B2 | Method for producing optically active alcohol | MITSUI CHEMICALS, INC. (JP) | 2013-10-22 | — | — | US | disclosed |
| US-20130012727-A1 | SYNTHESIS OF CLEISTANTHIN A AND DERIVATIVES THEREOF | GODAVARI BIOREFINERIES LIMITED | 2013-01-10 | — | — | US | disclosed |
| WO-2013001352-A2 | SYNTHESIS OF CLEISTANTHIN A AN DERIVATIVES THEREOF | GODAVARI BIOREFINERIES LIMITED (IN) | 2013-01-03 | — | — | WO | disclosed |
| US-20120088938-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-04-12 | — | — | US | disclosed |
| EP-2412694-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL | Mitsui Chemicals, Inc. (JP) | 2012-02-01 | — | — | EP | disclosed |
| EP-0704067-B1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG IND OHIO INC (US) | 2001-08-01 | — | — | EP | disclosed |
| EP-0704067-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0704067-A4 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES INC (US) | 1996-02-02 | — | — | EP | disclosed |
| US-5458815-A | Photochromic naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |
| US-5384077-A | Naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 1995-01-24 | — | — | US | disclosed |
| WO-1995000866-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1995-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012727-A1 | SYNTHESIS OF CLEISTANTHIN A AND DERIVATIVES THEREOF | STT3A, DDOST, MAGT1 | MAPK1 2393/4885CYP3A4 555/4885CYP1A2 541/4885 |
| US-20120088938-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL | ADH1A, ADH1C, FHIT | MAPK1 2126/4885CYP3A4 15/4885CYP1A2 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.