Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779434 | 0.83 | ADRA1D (0.48) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL4778958 | 0.83 | ADRA1D (0.48) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL4776370 | 0.82 | CHRM4 (0.42) | DRD2DRD4DRD3SLC6A2SLC6A4 | |
| SCHEMBL4780574 | 0.80 | CHRM4 (0.37) | — | |
| SCHEMBL4778369 | 0.79 | NOTUM (0.40) | DRD2DRD4DRD3 | |
| SCHEMBL4780977 | 0.75 | ALOX15 (0.38) | ADRA1ADRD2SLC6A2SLC6A4HTR1A | |
| SCHEMBL4780332 | 0.75 | CHRM4 (0.38) | DRD2DRD3SLC6A3 | |
| SCHEMBL4781028 | 0.75 | KDM4E (0.43) | ADRA1DADRA1AADRA1B | |
| SCHEMBL4321609 | 0.74 | GRM5 (0.42) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL4780326 | 0.74 | CHRM4 (0.40) | DRD2DRD3SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |