Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ACACB | O00763 | 4/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321609 | 0.82 | GRM5 (0.42) | CHRM4KMT2AGRM5RORC | |
| SCHEMBL4774664 | 0.80 | ADRA1D (0.38) | — | |
| SCHEMBL4781178 | 0.80 | UBE2M (0.39) | CHRM2LMNAKMT2ASMN1; SMN2RORC | |
| SCHEMBL4780326 | 0.80 | CHRM4 (0.40) | CHRM4HTTSMN1; SMN2RORC | |
| SCHEMBL4778369 | 0.79 | NOTUM (0.40) | CHRM4LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL4774338 | 0.76 | DRD2 (0.32) | CHRM4HTTSMN1; SMN2RORC | |
| SCHEMBL4779536 | 0.76 | DRD2 (0.32) | CHRM4HTTSMN1; SMN2RORC | |
| SCHEMBL4780332 | 0.73 | CHRM4 (0.38) | CHRM4KMT2ASMN1; SMN2 | |
| SCHEMBL4779787 | 0.73 | FFAR4 (0.38) | LMNAKMT2A | |
| SCHEMBL4779333 | 0.72 | CHRM4 (0.39) | CHRM4CHRM2CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |