Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYTH2 | Q99418 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780645 | 0.90 | PIK3CD (0.43) | ALDH1A1MCOLN3L3MBTL1PIK3CDPIK3CG | |
| SCHEMBL4781338 | 0.86 | SLC40A1 (0.48) | ALDH1A1LMNAHTTGAAKDM4E | |
| SCHEMBL4777554 | 0.85 | PKM (0.46) | ALDH1A1MCOLN3L3MBTL1PIK3CDPIK3CG | |
| SCHEMBL4781354 | 0.82 | BRAF (0.42) | POLBKDRMEN1KMT2ACCR2 | |
| SCHEMBL4780299 | 0.81 | CYP3A4 (0.41) | ALDH1A1LMNAPKMPOLBMEN1 | |
| SCHEMBL3091703 | 0.81 | CCR9 (0.43) | PIK3CDPIK3CGGAAMEN1KMT2A | |
| SCHEMBL4780017 | 0.81 | KAT6A (0.39) | ALDH1A1PIK3CDPIK3CGHTTGAA | |
| SCHEMBL4779280 | 0.79 | SLC40A1 (0.51) | LMNAGAATSHRMEN1KMT2A | |
| SCHEMBL4781379 | 0.76 | TSHR (0.46) | ALDH1A1LMNAHTTKDM4ETSHR | |
| SCHEMBL4781517 | 0.73 | MEN1 (0.41) | POLBKDRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |