Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780673 | 0.85 | CYP11B1 (0.45) | MEN1MAPTKMT2ALTB4RALOX5 | |
| SCHEMBL4796171 | 0.79 | PTH1R (0.46) | — | |
| SCHEMBL27994781 | 0.71 | — | — | |
| SCHEMBL6431579 | 0.70 | NUDT1 (0.43) | NPC1RAB9AALDH1A1 | |
| SCHEMBL4774100 | 0.68 | NOS3 (0.42) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL27651701 | 0.66 | MAPT (0.45) | NPC1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL4778323 | 0.66 | NOS3 (0.43) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL7150939 | 0.66 | NPC1 (0.67) | NPC1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL11783221 | 0.65 | ALDH1A1 (0.42) | NPC1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL4776778 | 0.65 | NFE2L2 (0.44) | MEN1ALDH1A1MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |