Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776572 | 0.85 | NPC1 (0.42) | LTB4RMEN1KMT2AMAPTALOX5 | |
| SCHEMBL4778107 | 0.81 | LTB4R (0.48) | CYP11B1CYP11B2CYP19A1LTB4RMEN1 | |
| SCHEMBL4796171 | 0.75 | PTH1R (0.46) | — | |
| SCHEMBL4774679 | 0.74 | RAB9A (0.43) | MEN1KMT2APOLBMAPTNPSR1 | |
| SCHEMBL4778137 | 0.71 | ALDH1A1 (0.48) | CYP11B1CYP11B2CYP19A1LTB4RMEN1 | |
| SCHEMBL4780655 | 0.69 | ALDH1A1 (0.46) | CYP11B1CYP11B2CYP19A1MEN1KMT2A | |
| SCHEMBL4774562 | 0.68 | CYP19A1 (0.42) | CYP11B1CYP11B2CYP19A1LTB4RMEN1 | |
| SCHEMBL4774580 | 0.68 | GRIN2B (0.40) | CYP11B1CYP11B2CYP19A1MEN1KMT2A | |
| SCHEMBL11292187 | 0.67 | KCNH2 (0.61) | MAPTCYP2C9HTT | |
| SCHEMBL28489642 | 0.66 | MEN1 (0.60) | MEN1KMT2APOLBMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |