SCHEMBL4777464

SCHEMBL4777464

CC(C)C(=O)Nc1nc(O)c2nc[nH]c2n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 2/20 0.41
ALDH1A1 P00352 3/20 0.39
HSD17B10 Q99714 2/20 0.39
LMNA P02545 1/20 0.39
NOS1 P29475 1/20 0.38
ADORA2A P29274 1/20 0.37
TSHR P16473 2/20 0.36
CDK5 Q00535 4/20 0.35
CDK5R1 Q15078 3/20 0.35
CCNE1 P24864 1/20 0.34
CDK2 P24941 1/20 0.34
NPC1 O15118 3/20 0.34
RAB9A P51151 3/20 0.34
KDM4E B2RXH2 2/20 0.34
HPGD P15428 2/20 0.34
TP53 P04637 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CDC7 O00311 1/20 0.34
SLC40A1 Q9NP59 1/20 0.33
RECQL P46063 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30590049 1.00 ADORA1 (0.41) ADORA1ALDH1A1HSD17B10LMNANOS1
SCHEMBL9412613 0.85 JAK3 (0.32) ALDH1A1HPGDSMN1; SMN2
SCHEMBL5483576 0.84 ADORA1 (0.40) ADORA1ALDH1A1HSD17B10LMNANOS1
SCHEMBL29665061 0.84 ADORA1 (0.40) ADORA1ALDH1A1HSD17B10LMNANOS1
SCHEMBL887124 0.83 CYP1A2 (0.40) ADORA1ALDH1A1LMNARAB9AKDM4E
SCHEMBL21050252 0.80 PRKD3 (0.42) ADORA1ALDH1A1HSD17B10LMNANOS1
SCHEMBL4777463 0.78 GDA (0.42) ADORA1ALDH1A1HSD17B10LMNANOS1
SCHEMBL9412566 0.78 KDM4E (0.35) ALDH1A1LMNANPC1RAB9AKDM4E
SCHEMBL9412633 0.77 ALDH1A1 (0.35) ALDH1A1KDM4EHPGDSMN1; SMN2
SCHEMBL377762 0.76 PDPK1 (0.33) LMNACDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7314923-B2 Nucleoside and oligonucleotide analogues DAIICHI SANKYO COMPANY, LIMITED (JP) 2008-01-01 US claimed
US-20260035403-A1 NUCLEOSIDE LINE-1 INHIBITORS TRANSPOSON THERAPEUTICS, INC. (US) 2026-02-05 US disclosed
US-20250215039-A1 NUCLEOSIDES FOR TREATING CANCER PRIMEFOUR THERAPEUTICS INC (US) 2025-07-03 US disclosed
EP-4499106-A2 NUCLEOSIDE LINE-1 INHIBITORS Transposon Therapeutics, Inc. (US) 2025-02-05 EP disclosed
CN-118146285-A Modified nucleoside, preparation method thereof, oligonucleotide prepared from modified nucleoside and application of oligonucleotide 北京悦康科创医药科技股份有限公司 2024-06-07 CN disclosed
WO-2023192499-A1 NUCLEOSIDES FOR TREATING CANCER PRIMEFOUR THERAPEUTICS, INC. (US) 2023-10-05 WO disclosed
WO-2023192491-A2 NUCLEOSIDE LINE-1 INHIBITORS TRANSPOSON THERAPEUTICS, INC. (US) 2023-10-05 WO disclosed
US-11213592-B2 Antibody-sting agonist conjugates and their use in immunotherapy IMMUNESENSOR THERAPEUTICS, INC. (US) 2022-01-04 US disclosed
US-20210290774-A1 ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY IMMUNESENSOR THERAPEUTICS, INC. (US) 2021-09-23 US disclosed
US-11033635-B2 Antibody-STING agonist conjugates and their use in immunotherapy IMMUNESENSOR THERAPEUTICS, INC. (US) 2021-06-15 US disclosed
US-20210015941-A1 ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY IMMUNESENSOR THERAPEUTICS, INC. (US) 2021-01-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11213592-B2 Antibody-sting agonist conjugates and their use in immunotherapy STING1, CGAS, MAVS ADORA1 378/4885ALDH1A1 4589/4885HSD17B10 4748/4885
US-20210290774-A1 ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY STING1, CGAS, MAVS ADORA1 378/4885ALDH1A1 4589/4885HSD17B10 4748/4885
US-20260035403-A1 NUCLEOSIDE LINE-1 INHIBITORS L3MBTL1, TDP1, TRDMT1 ADORA1 652/4885ALDH1A1 1904/4885HSD17B10 3176/4885
US-11033635-B2 Antibody-STING agonist conjugates and their use in immunotherapy STING1, CGAS, MAVS ADORA1 378/4885ALDH1A1 4589/4885HSD17B10 4748/4885
US-20250215039-A1 NUCLEOSIDES FOR TREATING CANCER UNG, OGG1, NTPCR ADORA1 427/4885ALDH1A1 635/4885HSD17B10 1666/4885
US-20210015941-A1 ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY STING1, CGAS, MAVS ADORA1 378/4885ALDH1A1 4589/4885HSD17B10 4748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.