Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778391 | 0.82 | NOS3 (0.38) | NOS3NOS1NOS2MAPTMEN1 | |
| SCHEMBL4774798 | 0.75 | NOS3 (0.42) | NOS3NOS1NOS2MAOBMAPT | |
| SCHEMBL4796742 | 0.75 | MAOA (0.47) | MAOBMAOA | |
| SCHEMBL22086956 | 0.73 | ADORA1 (0.51) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL4778323 | 0.72 | NOS3 (0.43) | NOS3NOS1NOS2MAOBMAPT | |
| SCHEMBL4774672 | 0.72 | NOS3 (0.43) | NOS3NOS1NOS2MAOBMAPT | |
| SCHEMBL4774100 | 0.71 | NOS3 (0.42) | NOS3NOS1NOS2MAOBMAPT | |
| SCHEMBL4781142 | 0.71 | ALDH1A1 (0.48) | NOS3NOS1NOS2MAOBMAPT | |
| SCHEMBL4774626 | 0.71 | NOS3 (0.43) | NOS3NOS1NOS2MAOBMAPT | |
| SCHEMBL4776700 | 0.71 | HRH2 (0.42) | NOS3NOS1NOS2MAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |