Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | CCR3 | P51677 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819684 | 0.77 | P2RX1 (0.33) | MAOAMAOBOPRM1 | |
| SCHEMBL9621163 | 0.73 | LMNA (0.38) | LMNACYP2A6MAOAMAOBKDM1A | |
| 1,4-Dichlorobenzene SCHEMBL5191 | 0.63 | — | — | |
| 1,4-Dichlorobenzene SCHEMBL11243685 | 0.63 | — | — | |
| SCHEMBL668905 | 0.62 | SLC6A4 (0.47) | LMNACYP2A6MAOAMAOBKDM1A | |
| SCHEMBL8204734 | 0.62 | LMNA (0.42) | LMNACYP2A6MAOAMAOBKDM1A | |
| SCHEMBL11472006 | 0.60 | TSHR (0.41) | LMNACYP2A6MAOAMAOBKDM1A | |
| SCHEMBL28574237 | 0.60 | MAOA (0.40) | LMNACYP2A6MAOAMAOBKDM1A | |
| SCHEMBL9735920 | 0.60 | CCNB2 (0.47) | LMNACYP2A6MAOAMAOBKDM1A | |
| 1,4-Dichlorobenzene SCHEMBL8166345 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008005368-A2 | PIPERAZINES AS P2X7 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-01-10 | — | — | WO | disclosed |