Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.44 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CCR9 | P51686 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | USP9X | Q93008 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18315257 | 0.87 | KEAP1 (0.50) | KEAP1NFE2L2SLC40A1GLO1KMT2A | |
| SCHEMBL30304671 | 0.87 | KEAP1 (0.50) | KEAP1NFE2L2SLC40A1GLO1KMT2A | |
| SCHEMBL4780017 | 0.86 | KAT6A (0.39) | SLC40A1PGAM1KMT2AMEN1GAA | |
| SCHEMBL3098055 | 0.86 | AXL (0.52) | KEAP1NFE2L2SLC40A1GLO1PGAM1 | |
| SCHEMBL31478916 | 0.83 | AXL (0.53) | KEAP1NFE2L2SLC40A1GLO1KMT2A | |
| SCHEMBL3097960 | 0.83 | AXL (0.53) | KEAP1NFE2L2SLC40A1GLO1KMT2A | |
| SCHEMBL4780415 | 0.83 | MEN1 (0.57) | KEAP1NFE2L2KMT2AMEN1TDP1 | |
| SCHEMBL4777554 | 0.82 | PKM (0.46) | KEAP1NFE2L2KMT2AMEN1GAA | |
| SCHEMBL3095654 | 0.81 | STAT3 (0.51) | KEAP1NFE2L2GLO1KMT2AMEN1 | |
| SCHEMBL4777374 | 0.80 | GLO1 (0.43) | GLO1KMT2AMEN1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |