Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT5 | Q96KN8 | 17/20 | 0.71 |
| ▸ | PLAAT4 | Q9UL19 | 17/20 | 0.71 |
| ▸ | PLAAT3 | P53816 | 16/20 | 0.71 |
| ▸ | PLAAT2 | Q9NWW9 | 16/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779588 | 0.96 | PLAAT5 (0.72) | PLAAT5PLAAT4PLAAT3PLAAT2L3MBTL1 | |
| SCHEMBL2770651 | 0.85 | PLAAT5 (0.79) | PLAAT5PLAAT4PLAAT3PLAAT2L3MBTL1 | |
| SCHEMBL162806 | 0.85 | HDAC1 (0.62) | L3MBTL1KDM4ELMNA | |
| Phosphine SCHEMBL27480219 | 0.83 | HDAC1 (0.60) | L3MBTL1KDM4ELMNA | |
| SCHEMBL27742435 | 0.81 | PLAAT5 (0.77) | PLAAT5PLAAT4PLAAT3PLAAT2L3MBTL1 | |
| SCHEMBL2770463 | 0.81 | PLAAT5 (0.80) | PLAAT5PLAAT4PLAAT3PLAAT2L3MBTL1 | |
| SCHEMBL1233076 | 0.81 | LMNA (0.63) | L3MBTL1KDM4ELMNA | |
| SCHEMBL9231881 | 0.81 | HDAC1 (0.60) | PLAAT5PLAAT4PLAAT3PLAAT2 | |
| SCHEMBL117432 | 0.80 | MAPT (0.61) | PLAAT5PLAAT4PLAAT3PLAAT2KDM4E | |
| SCHEMBL8358014 | 0.80 | L3MBTL1 (0.71) | L3MBTL1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745489-B2 | Compositions and methods for inhibition of phospholipase A2 mediated inflammation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-29 | — | — | US | disclosed |
| US-7745489-B2 | Compositions and methods for inhibition of phospholipase A2 mediated inflammation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-29 | — | — | US | disclosed |
| US-20080319065-A1 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-12-25 | — | — | US | disclosed |
| US-20080319065-A1 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-12-25 | — | — | US | disclosed |
| US-20080319065-A1 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-12-25 | — | — | US | disclosed |
| EP-1937247-A2 | SYSTEMIC AND INTRATHECAL EFFECTS OF A NOVEL SERIES OF PHOSPHOLIPASE A2 INHIBITORS ON HYPERALGESIA AND SPINAL PGE2 RELEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007022443-A2 | SYSTEMIC AND INTRATHECAL EFFECTS OF A NOVEL SERIES OF PHOSPHOLIPASE A2 INHIBITORS ON HYPERALGESIA AND SPINAL PGE2 RELEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319065-A1 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release | PLA2G4A, PLA2G4B, PLA2G2A | PLAAT5 106/4885PLAAT4 45/4885PLAAT3 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.