Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778087 | 0.94 | KIF11 (0.47) | KIF11HRH3KCNH2ACHEP2RX7 | |
| SCHEMBL4021692 | 0.89 | ALDH1A1 (0.38) | KIF11KDM4EALDH1A1 | |
| SCHEMBL4780207 | 0.87 | L3MBTL1 (0.37) | KIF11ALDH1A1KCNH2RORCCCR5 | |
| SCHEMBL4772352 | 0.87 | L3MBTL1 (0.37) | KIF11ALDH1A1KCNH2RORCCCR5 | |
| SCHEMBL4776377 | 0.87 | KCNH2 (0.42) | KIF11ALDH1A1KCNH2RORC | |
| SCHEMBL4026853 | 0.87 | KIF11 (0.38) | KIF11HRH3RORC | |
| SCHEMBL4019939 | 0.87 | KIF11 (0.38) | KIF11HRH3RORC | |
| SCHEMBL4019937 | 0.87 | KIF11 (0.38) | KIF11HRH3RORC | |
| SCHEMBL4024639 | 0.87 | OPRM1 (0.36) | KIF11HRH3KCNH2RORCCCR5 | |
| SCHEMBL4024642 | 0.87 | OPRM1 (0.36) | KIF11HRH3KCNH2RORCCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |