SCHEMBL4782024

SCHEMBL4782024

O=c1cc(C(F)(F)F)[nH]c(=O)n1Cc1c(F)cc(Cl)c2nc(C(F)(F)F)[nH]c12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRAP1 Q12931 6/20 0.38
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
HSP90AA1 P07900 4/20 0.35
HSP90B1 P14625 4/20 0.35
BCAT1 P54687 5/20 0.35
BCAT2 O15382 4/20 0.35
KMT2A Q03164 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
NPC1 O15118 2/20 0.34
TLR7 Q9NYK1 1/20 0.34
MEN1 O00255 1/20 0.34
GAA P10253 1/20 0.34
RAB9A P51151 1/20 0.34
RAD51 Q06609 1/20 0.32
TSHR P16473 2/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
USP2 O75604 1/20 0.32
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17240320 0.91 TRAP1 (0.36) TRAP1ALDH1A1KDM4EHSP90AA1HSP90B1
SCHEMBL7574968 0.80 BCAT1 (0.43) ALDH1A1BCAT1BCAT2SMN1; SMN2TSHR
SCHEMBL8336400 0.78 TRAP1 (0.35) TRAP1ALDH1A1KDM4EBCAT1BCAT2
SCHEMBL7574972 0.76 BCAT1 (0.43) ALDH1A1BCAT1BCAT2SMN1; SMN2TSHR
SCHEMBL7558600 0.68 CSNK2A1 (0.40) KDM4EKMT2AMEN1GAATSHR
SCHEMBL10696215 0.67 HSP90AA1 (0.43) TRAP1ALDH1A1KDM4EHSP90AA1HSP90B1
SCHEMBL8525560 0.66 ALDH1A1 (0.50) ALDH1A1KDM4EKMT2ASMN1; SMN2NPC1
SCHEMBL8820735 0.65 ALDH1A1 (0.43) TRAP1ALDH1A1KDM4EHSP90AA1HSP90B1
SCHEMBL4782020 0.65 USP2 (0.36) SMN1; SMN2TSHRUSP2HPGD
SCHEMBL3774414 0.65 USP2 (0.32) TSHRUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008008933-A2 METHOD OF CONTROLLING WEEDS FMC CORPORATION (US) 2008-01-17 WO disclosed