Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 4/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4840971 | 0.88 | ALDH1A1 (0.47) | SLC40A1GLO1CYP2C9CYP2C19EDNRB | |
| SCHEMBL4727568 | 0.86 | GFER (0.43) | GLO1CYP2C9CYP2C19SCN9AHPGD | |
| SCHEMBL4781821 | 0.85 | SLC40A1 (0.49) | SLC40A1GLO1CCR1CCR2CCR4 | |
| SCHEMBL4777374 | 0.85 | GLO1 (0.43) | GLO1CYP2C9CYP2C19PGRFBP1 | |
| SCHEMBL4775751 | 0.83 | SLC40A1 (0.44) | SLC40A1GLO1CYP2C9CYP2C19CCR1 | |
| SCHEMBL3098833 | 0.82 | SLC40A1 (0.55) | SLC40A1CCR2PGRKDM1AACLY | |
| SCHEMBL4781817 | 0.81 | SLC40A1 (0.48) | SLC40A1CCR1CCR2CCR4PGR | |
| SCHEMBL4782048 | 0.80 | PGR (0.54) | SLC40A1GLO1CCR4PGRKDM1A | |
| SCHEMBL3095682 | 0.78 | PIK3C2B (0.36) | PGRKDM1AMAOAACLYSCN9A | |
| SCHEMBL8662810 | 0.76 | HPGD (0.51) | PGRKDM1AMAOAACLYHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |