Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | CCR8 | P51685 | 9/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.41 |
| ▸ | WNT3 | P56703 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782099 | 0.89 | SFRP1 (0.51) | HTR6CCR8SFRP1WNT3BRD4 | |
| SCHEMBL4784223 | 0.86 | HTR1A (0.42) | HTR6CCR8SFRP1WNT3 | |
| SCHEMBL4782603 | 0.85 | BRD4 (0.43) | HTR6CCR8BRD4 | |
| SCHEMBL4782711 | 0.85 | HTR6 (0.52) | HTR6SFRP1WNT3 | |
| SCHEMBL4782800 | 0.84 | CTSB (0.39) | HTR6SFRP1WNT3 | |
| SCHEMBL4783460 | 0.84 | SFRP1 (0.50) | SFRP1WNT3 | |
| SCHEMBL4785454 | 0.81 | CCR8 (0.51) | CCR8 | |
| SCHEMBL4783673 | 0.80 | CCR8 (0.51) | CCR8 | |
| SCHEMBL4879740 | 0.79 | SFRP1 (0.47) | SFRP1WNT3 | |
| SCHEMBL4783752 | 0.78 | SFRP1 (0.47) | SFRP1WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |