Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 7/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782615 | 0.89 | NPC1 (0.46) | NPC1PKMALDH1A1GBA1MEN1 | |
| SCHEMBL4782093 | 0.88 | NPC1 (0.48) | NPC1PKMALDH1A1GBA1MEN1 | |
| SCHEMBL4782077 | 0.88 | NPC1 (0.44) | NPC1PKMALDH1A1GBA1MEN1 | |
| SCHEMBL4783430 | 0.86 | CNR2 (0.48) | NPC1PKMALDH1A1GBA1HTR6 | |
| SCHEMBL4781316 | 0.85 | HTR6 (0.43) | ALDH1A1HTR6 | |
| SCHEMBL4780971 | 0.79 | BRD4 (0.45) | NPC1HTR6 | |
| SCHEMBL4783889 | 0.79 | BRD4 (0.43) | NPC1HTR6 | |
| SCHEMBL4782603 | 0.75 | BRD4 (0.43) | ALDH1A1HTR6 | |
| SCHEMBL4784291 | 0.73 | TDP1 (0.54) | PKMALDH1A1MEN1KMT2AHTR6 | |
| SCHEMBL4800128 | 0.73 | HTR6 (0.43) | ALDH1A1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |