Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454671 | 0.80 | HTR6 (0.46) | HTR6GAAALDH1A1KMT2APOLB | |
| SCHEMBL22028032 | 0.79 | POLB (0.50) | HTR6GAAALDH1A1KMT2APOLB | |
| SCHEMBL28252471 | 0.79 | HTR6 (0.45) | HTR6GAAALDH1A1KDM4EPKM | |
| SCHEMBL6971370 | 0.78 | KMT2A (0.68) | HTR6ALDH1A1KMT2APOLBGFER | |
| SCHEMBL30751995 | 0.77 | HTR6 (1.00) | HTR6GAAALDH1A1KDM4EHPGD | |
| SCHEMBL395274 | 0.77 | HTR6 (1.00) | HTR6GAAALDH1A1KDM4EHPGD | |
| SCHEMBL28330197 | 0.76 | HTR6 (0.46) | HTR6GAAALDH1A1KDM4EPKM | |
| SCHEMBL6963366 | 0.76 | ALDH1A1 (0.48) | HTR6GAAALDH1A1KDM4EHPGD | |
| SCHEMBL1691772 | 0.75 | HTR6 (0.45) | HTR6GAAALDH1A1KMT2ALMNA | |
| SCHEMBL5451015 | 0.75 | HTR6 (0.65) | HTR6GAAALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061160-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |