Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 2/20 | 0.50 |
| ▸ | TDP2 | O95551 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 8/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29355977 | 0.88 | DHODH (0.51) | APAF1TDP2DHODHMAPK1TSHR | |
| SCHEMBL8459324 | 0.80 | APAF1 (0.60) | APAF1TDP2DHODHMAPK1TSHR | |
| SCHEMBL14439382 | 0.79 | LCK (0.46) | KMT2AMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL3332517 | 0.78 | DNMT1 (0.44) | MAPK1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL8459098 | 0.78 | MAPT (0.55) | TDP2DHODHMAPK1MEN1KMT2A | |
| SCHEMBL3333270 | 0.77 | PTPN1 (0.33) | DHODHMAPTPOLBCES2CES1 | |
| SCHEMBL29359488 | 0.76 | APEX1 (0.38) | APAF1TDP2DHODHMAPK1TSHR | |
| SCHEMBL8446033 | 0.76 | APEX1 (0.38) | APAF1TDP2DHODHMAPK1TSHR | |
| SCHEMBL12715781 | 0.74 | DHODH (0.41) | APAF1TDP2DHODHMAPK1TSHR | |
| SCHEMBL8405065 | 0.74 | APAF1 (0.52) | APAF1TDP2DHODHMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997018800-A1 | USE OF NAPHTHOQUINONE COMPOUNDS AS ANTIPROTOZOAL AGENTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-05-29 | — | — | WO | claimed |
| WO-2008136642-A1 | NAPHTHOQUINONE-BASED PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF DISEASES INVOLVING OBESITY, DIABETES, METABOLIC SYNDROME, NEURO-DEGENERATIVE DISEASES AND MITOCHONDRIA DYSFUNCTION DISEASES | MAZENCE INC. (KR) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008066300-A1 | NAPHTHOQUINONE-BASED PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF DISEASES INVOLVING OBESITY, DIABETES, METABOLIC SYNDROME, NEURO-DEGENERATIVE DISEASES AND MITOCHONDRIA DYSFUNCTION DISEASES | MAZENCE INC. (KR) | 2008-06-05 | — | — | WO | disclosed |
| EP-0888326-B1 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RES FOUND (US) | 2006-08-16 | — | — | EP | disclosed |
| US-5969163-A | CONTACTING SOLUTION OF LAWSONE IN DIMETHYL SULFOXIDE AT LOW TEMPERATURE WITH LITHIUM HYDRIDE AND WARMING TO FORM LITHIUM SALT, ALKYLATING WITH ALLYL HALIDE IN PRESENCE OF LITHIUM IODIDE, CYCLIZING ALKYLATED LAWSONE DERIVATIVES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-10-19 | — | — | US | disclosed |
| US-5962002-A | 1,1,4,4-SUBSTITUTED DIHYDRONAPHTHALENE COMPOUNDS | BTG INTERNATIONAL LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| EP-0759898-B1 | NAPHTHOQUINONE DERIVATIVES | BTG INT LTD (GB) | 1999-07-14 | — | — | EP | disclosed |
| EP-0802730-B1 | PESTICIDAL COMPOUNDS | BTG INT LTD (GB) | 1999-06-23 | — | — | EP | disclosed |
| US-5886027-A | DUNNIONE A PLANT EXTRACT OBTAINABLE FROM STREPTOCARPUS DUNNII OR CALCEOLARIA INTEGRIFOLIA | BTG INTERNATIONAL LIMITED (GB) | 1999-03-23 | — | — | US | disclosed |
| EP-0888326-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-01-07 | — | — | EP | disclosed |
| US-5834515-A | PESTICIDE; TREATING WITH A PLANT EXTRACT FROM A CALCEOLARIA SPECIES | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1998-11-10 | — | — | US | disclosed |
| US-5824700-A | ANTICARCINOGENIC AGENTS FOR TREATING BREAST CANCER OR COLON CANCER | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1998-10-20 | — | — | US | disclosed |
| EP-0861028-A1 | FUNGICIDAL COMPOUNDS (B) | BTG INTERNATIONAL LIMITED (GB) | 1998-09-02 | — | — | EP | disclosed |
| EP-0802730-A1 | PESTICIDAL COMPOUNDS | BTG INTERNATIONAL LIMITED (GB) | 1997-10-29 | — | — | EP | disclosed |
| WO-1997031936-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1997-09-04 | — | — | WO | disclosed |
| WO-1997018800-A1 | USE OF NAPHTHOQUINONE COMPOUNDS AS ANTIPROTOZOAL AGENTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |
| WO-1997016970-A1 | FUNGICIDAL COMPOUNDS (B) | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-05-15 | — | — | WO | disclosed |
| EP-0759898-A1 | NAPHTHOQUINONE DERIVATIVES | BTG INTERNATIONAL LIMITED (GB) | 1997-03-05 | — | — | EP | disclosed |
| WO-1996021355-A1 | PESTICIDAL COMPOUNDS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1996-07-18 | — | — | WO | disclosed |
| WO-1995032176-A1 | NAPHTHOQUINONE DERIVATIVES | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-11-30 | — | — | WO | disclosed |