Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 18/20 | 0.58 |
| ▸ | PRKAA1 | Q13131 | 18/20 | 0.58 |
| ▸ | PRKAB1 | Q9Y478 | 18/20 | 0.58 |
| ▸ | PRKAB2 | O43741 | 17/20 | 0.58 |
| ▸ | PRKAA2 | P54646 | 17/20 | 0.58 |
| ▸ | PRKAG3 | Q9UGI9 | 17/20 | 0.58 |
| ▸ | PRKAG2 | Q9UGJ0 | 17/20 | 0.58 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15300856 | 0.86 | PRKAG1 (0.53) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL13632234 | 0.79 | PRKAG1 (0.53) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL956608 | 0.79 | PRKAG1 (0.55) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL2816583 | 0.79 | MAP2K4 (0.61) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL4782757 | 0.78 | PRKAB2 (0.61) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL17452077 | 0.75 | PRKAB2 (1.00) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL23858844 | 0.75 | HCAR2 (0.44) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL2919160 | 0.75 | PRKAG1 (0.48) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL30050008 | 0.75 | HCAR2 (0.44) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL27363663 | 0.74 | PRKAA1 (0.57) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260022131-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2026-01-22 | — | — | US | disclosed |
| US-12473302-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-11-18 | — | — | US | disclosed |
| US-20240287092-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-08-29 | — | — | US | disclosed |
| US-11919913-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-03-05 | — | — | US | disclosed |
| US-20210363155-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-11-25 | — | — | US | disclosed |
| US-11028098-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3495357-B1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | UNIV COLUMBIA (US) | 2021-05-05 | — | — | EP | disclosed |
| EP-3747888-A1 | NITROGENATED HETEROCYCLIC AMIDE COMPOUND, AND USE THEREOF FOR MEDICAL PURPOSES | Japan Tobacco Inc. (JP) | 2020-12-09 | — | — | EP | disclosed |
| EP-3495357-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | The Trustees of Columbia University in the City of New York (US) | 2019-06-12 | — | — | EP | disclosed |
| US-10273243-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-04-30 | — | — | US | disclosed |
| US-20190031681-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-01-31 | — | — | US | disclosed |
| EP-2968304-B1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | UNIV COLUMBIA (US) | 2018-10-10 | — | — | EP | disclosed |
| US-20160046648-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-02-18 | — | — | US | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| US-5166341-A | Selective antagonist of serotonin 3(5-HT3) receptor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0358903-A2 | Indazole-3-carboxylic acid derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273243-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, CYP4F3 | PRKAG1 4242/4885PRKAA1 3284/4885PRKAB1 4026/4885 |
| US-20240287092-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HTR3C, HRH4, DRD3 | PRKAG1 4137/4885PRKAA1 3186/4885PRKAB1 3838/4885 |
| US-12473302-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, DRD3 | PRKAG1 4137/4885PRKAA1 3186/4885PRKAB1 3838/4885 |
| US-11919913-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, CYP4F3 | PRKAG1 4148/4885PRKAA1 3208/4885PRKAB1 3849/4885 |
| US-20210363155-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HTR3C, HRH4, CYP4F3 | PRKAG1 4148/4885PRKAA1 3208/4885PRKAB1 3849/4885 |
| US-20160046648-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HTR3C, HRH4, CYP4F3 | PRKAG1 4242/4885PRKAA1 3284/4885PRKAB1 4026/4885 |
| US-11028098-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, CYP4F3 | PRKAG1 4178/4885PRKAA1 3333/4885PRKAB1 3979/4885 |
| US-20190031681-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HTR3C, HRH4, CYP4F3 | PRKAG1 4178/4885PRKAA1 3333/4885PRKAB1 3979/4885 |
| US-20260022131-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | CLN6, NR2E3, CBR3 | PRKAG1 2139/4885PRKAA1 1337/4885PRKAB1 1838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.