Sugi Predict

Sugi Predict / Compounds / SCHEMBL2816583

SCHEMBL2816583

SCHEMBL2816583

O=C(O)c1n[nH]c2cc(F)ccc12

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MAP2K4 P45985 8/20 0.61
▸ MAPK1 P28482 1/20 0.61
▸ MAPK6 Q16659 1/20 0.61
▸ PRKAG1 P54619 7/20 0.49
▸ PRKAA1 Q13131 7/20 0.49
▸ PRKAB1 Q9Y478 7/20 0.49
▸ PRKAB2 O43741 6/20 0.49
▸ PRKAA2 P54646 6/20 0.49
▸ PRKAG3 Q9UGI9 6/20 0.49
▸ PRKAG2 Q9UGJ0 6/20 0.49
▸ MAP2K7 O14733 1/20 0.46
▸ RBP4 P02753 1/20 0.46
▸ MAPT P10636 1/20 0.44
▸ HAO1 Q9UJM8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL956608 0.86 PRKAG1 (0.55) MAP2K4MAPK1MAPK6PRKAG1PRKAA1
SCHEMBL16252829 0.85 MAP2K4 (0.52) MAP2K4MAPK1MAPK6MAP2K7RBP4
SCHEMBL31725376 0.81 MAP2K4 (0.65) MAP2K4MAPK1MAPK6MAP2K7MAPT
SCHEMBL15882110 0.81 MAP2K4 (0.65) MAP2K4MAPK1MAPK6MAP2K7MAPT
SCHEMBL12879075 0.81 PRKAG1 (0.46) MAP2K4PRKAG1PRKAA1PRKAB1PRKAB2
SCHEMBL176936 0.81 PRKAG1 (0.55) PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2
SCHEMBL11165259 0.80 MAP2K4 (0.44) MAP2K4MAPK1MAPK6
SCHEMBL261067 0.79 IDO1 (0.62) PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2
SCHEMBL7379535 0.79 MAP2K4 (0.61) MAP2K4MAPK1PRKAG1PRKAA1PRKAB1
SCHEMBL2919160 0.79 PRKAG1 (0.48) PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2718271-B1 SUBSTITUTED BENZAMIDE DERIVATIVES HOFFMANN LA ROCHE (CH) 2015-08-12 — — EP claimed
US-9029370-B2 Substituted benzamide derivatives HOFFMANN-LA ROCHE INC. (US) 2015-05-12 — — US claimed
EP-2718271-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2014-04-16 — — EP claimed
WO-2012168265-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2012-12-13 — — WO claimed
US-20120316165-A1 SUBSTITUTED BENZAMIDE DERIVATIVES HOFFMANN-LA ROCHE INC. 2012-12-13 — — US claimed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 — — US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 — — EP disclosed
US-20260022131-A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2026-01-22 — — US disclosed
US-12473302-B2 4-phenylpiperidines, their preparation and use THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2025-11-18 — — US disclosed
US-20250092014-A1 COMPOUNDS AND METHODS OF ACTIVATING LIPOPROTEIN LIPASE METREA BIOSCIENCES INC (US) 2025-03-20 — — US disclosed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 — — CN disclosed
US-20240287092-A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-08-29 — — US disclosed
US-20060014756-A1 Benzimidazoles AVENTIS PHARMACEUTICALS INC. (US) 2006-01-19 — — US disclosed
US-6897208-B2 Benzimidazoles AVENTIS PHARMACEUTICALS INC. (US) 2005-05-24 — — US disclosed
EP-1441725-A1 BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS Aventis Pharmaceuticals Inc. (US) 2004-08-04 — — EP disclosed
US-20040048868-A1 Benzimidazoles AVENTISUB LLC 2004-03-11 — — US disclosed
WO-2003035065-A1 BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS AVENTIS PHARMACEUTICALS INC (US) 2003-05-01 — — WO disclosed
US-5166341-A Selective antagonist of serotonin 3(5-HT3) receptor DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1992-11-24 — — US disclosed
US-5017573-A Serotonin receptor antagonist DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1991-05-21 — — US disclosed
EP-0358903-A2 Indazole-3-carboxylic acid derivatives DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1990-03-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060014756-A1 Benzimidazoles CDK9, BMX, SBK3 MAP2K4 252/4885MAPK1 154/4885MAPK6 112/4885
US-20240287092-A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE HTR3C, HRH4, DRD3 MAP2K4 643/4885MAPK1 1985/4885MAPK6 2802/4885
US-20040048868-A1 Benzimidazoles CDK9, BMX, CDKN1A MAP2K4 376/4885MAPK1 23/4885MAPK6 103/4885
US-12473302-B2 4-phenylpiperidines, their preparation and use HTR3C, HRH4, DRD3 MAP2K4 643/4885MAPK1 1985/4885MAPK6 2802/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH MAP2K4 3584/4885MAPK1 4010/4885MAPK6 4205/4885
US-20120316165-A1 SUBSTITUTED BENZAMIDE DERIVATIVES NPY4R, PER2, NPY1R MAP2K4 2118/4885MAPK1 3747/4885MAPK6 4404/4885
US-20250092014-A1 COMPOUNDS AND METHODS OF ACTIVATING LIPOPROTEIN LIPASE LPL, LIPA, PNLIP MAP2K4 3679/4885MAPK1 2239/4885MAPK6 2300/4885
US-20260022131-A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE CLN6, NR2E3, CBR3 MAP2K4 3160/4885MAPK1 3088/4885MAPK6 3940/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.