Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.45 |
| ▸ | PPARA | Q07869 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738692 | 0.80 | PPARA (0.65) | PPARGPPARAHTTSMN1; SMN2STAT3 | |
| SCHEMBL4740398 | 0.78 | HTT (0.40) | PPARGPPARAHTTSMN1; SMN2STAT3 | |
| SCHEMBL4740384 | 0.76 | L3MBTL1 (0.52) | HTTSMN1; SMN2STAT3L3MBTL1ALDH1A1 | |
| SCHEMBL30986715 | 0.73 | L3MBTL1 (0.55) | HTTSMN1; SMN2STAT3L3MBTL1ALDH1A1 | |
| SCHEMBL1551850 | 0.70 | L3MBTL1 (0.55) | HTTSMN1; SMN2STAT3L3MBTL1LMNA | |
| SCHEMBL31574614 | 0.70 | L3MBTL1 (0.55) | HTTSMN1; SMN2STAT3L3MBTL1ALDH1A1 | |
| SCHEMBL28485531 | 0.70 | L3MBTL1 (0.64) | HTTSMN1; SMN2STAT3L3MBTL1ALDH1A1 | |
| SCHEMBL22397981 | 0.68 | LMNA (0.53) | HTTSMN1; SMN2L3MBTL1LMNAHPGD | |
| SCHEMBL4740388 | 0.67 | ALDH1A1 (0.69) | HTTSMN1; SMN2STAT3L3MBTL1ALDH1A1 | |
| SCHEMBL6566120 | 0.65 | HTT (0.59) | HTTSMN1; SMN2STAT3L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008081096-A2 | QUINOLINYL DERIVATIVES, METHOD FOR PREPARING SAME, PHARMACEUTIC COMPOSITIONS CONTAINING SAME, AND USE THEREOF AS HYPOGLYCEMIANT AND HYPOLIPEMIANT AGENTS | LES LABORATOIRES SERVIER (FR) | 2008-07-10 | — | — | WO | disclosed |