Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | PYCR1 | P32322 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5513951 | 0.79 | MMP13 (0.39) | USP2LOXL2CHRM5CHKASMN1; SMN2 | |
| SCHEMBL3267766 | 0.78 | MAOB (0.59) | USP2MAOBSMN1; SMN2CYP3A4PYCR1 | |
| SCHEMBL27947483 | 0.75 | SMN1; SMN2 (0.50) | LOXL2CHRM5CHKASMN1; SMN2KDM4E | |
| SCHEMBL1602718 | 0.75 | ALDH1A1 (0.56) | LOXL2CHRM5CHKASMN1; SMN2KDM4E | |
| SCHEMBL30093206 | 0.73 | KDM4E (0.53) | MAOBLOXL2CHRM5CHKASMN1; SMN2 | |
| SCHEMBL4739963 | 0.72 | PYCR1 (0.64) | SMN1; SMN2CYP3A4PYCR1LMNATSHR | |
| SCHEMBL22928691 | 0.71 | CYP1A2 (0.44) | LOXL2CHRM5CHKASMN1; SMN2KDM4E | |
| SCHEMBL12827301 | 0.71 | LOXL2 (0.42) | USP2LOXL2CHRM5CHKASMN1; SMN2 | |
| SCHEMBL7837873 | 0.71 | LOXL2 (0.42) | USP2LOXL2CHRM5CHKASMN1; SMN2 | |
| SCHEMBL19688314 | 0.71 | PYCR1 (0.60) | USP2MAOBLOXL2HDAC8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-B1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-10-22 | — | — | EP | claimed |
| EP-1416933-B1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM INC (US) | 2008-01-02 | — | — | EP | claimed |