Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786534 | 0.84 | MTNR1A (0.54) | MTNR1AMTNR1BKCNH2SCN9ASCN5A | |
| SCHEMBL4788581 | 0.81 | HTR7 (0.47) | HTR7MTNR1AMTNR1BHTR1AHTR2A | |
| SCHEMBL4788572 | 0.80 | MTNR1A (0.51) | MTNR1AMTNR1BKCNH2SCN9ASCN5A | |
| SCHEMBL4788623 | 0.74 | DRD2 (0.56) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL4786508 | 0.74 | DRD2 (0.56) | MTNR1AMTNR1BKCNH2CYP1A2MAPT | |
| SCHEMBL4789252 | 0.74 | KCNH2 (0.50) | HTR7MTNR1AMTNR1BKCNH2SCN9A | |
| SCHEMBL839817 | 0.73 | SCN9A (0.54) | MTNR1AMTNR1BKCNH2SCN9ASCN5A | |
| SCHEMBL4788553 | 0.72 | KCNH2 (0.55) | MTNR1AMTNR1BKCNH2SCN9ACYP1A2 | |
| SCHEMBL4788836 | 0.72 | HRH3 (0.54) | CYP1A2 | |
| SCHEMBL4746920 | 0.71 | KCNH2 (0.61) | MTNR1AMTNR1BKCNH2SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |