Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897672 | 0.90 | FFAR2 (0.40) | FFAR2ALDH1A1RECQLHDAC4LMNA | |
| SCHEMBL4789019 | 0.80 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL4788948 | 0.75 | KMT2A (0.43) | ALDH1A1LMNASMN1; SMN2L3MBTL1HDAC1 | |
| SCHEMBL4891786 | 0.71 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2NPSR1MAPT | |
| SCHEMBL4885880 | 0.70 | CNR1 (0.39) | ALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3441524 | 0.69 | RECQL (0.45) | FFAR2ALDH1A1RECQLHDAC4LMNA | |
| SCHEMBL27732382 | 0.67 | SMN1; SMN2 (0.45) | ALDH1A1RECQLLMNASMN1; SMN2GAA | |
| SCHEMBL4788013 | 0.67 | ENPP2 (0.43) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4749922 | 0.66 | KDM4E (0.45) | ALDH1A1LMNASMN1; SMN2L3MBTL1GAA | |
| SCHEMBL28581488 | 0.65 | SMN1; SMN2 (0.54) | ALDH1A1HDAC4LMNASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |