Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.55 |
| ▸ | NOS3 | P29474 | 3/20 | 0.53 |
| ▸ | NOS1 | P29475 | 3/20 | 0.53 |
| ▸ | NOS2 | P35228 | 2/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 5/20 | 0.52 |
| ▸ | HTR1B | P28222 | 5/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | HTR1F | P30939 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2936288 | 0.80 | HTR1D (0.60) | MPOHTR1DHTR1BHTR2A | |
| SCHEMBL3379714 | 0.72 | SLC6A4 (0.70) | SLC6A4NOS3NOS1NOS2MPO | |
| SCHEMBL24497000 | 0.70 | SLC6A4 (1.00) | SLC6A4MPOHTR1DHTR1BHTR1A | |
| SCHEMBL1122330 | 0.69 | NOS3 (0.61) | SLC6A4NOS3NOS1NOS2MPO | |
| SCHEMBL1122333 | 0.69 | NOS3 (1.00) | SLC6A4NOS3NOS1NOS2CYP2D6 | |
| SCHEMBL27832501 | 0.69 | MTNR1A (0.33) | MTNR1AMTNR1B | |
| SCHEMBL3377485 | 0.69 | SLC6A4 (1.00) | SLC6A4MPOHTR1DHTR1BHTR1A | |
| SCHEMBL4630455 | 0.69 | HTR1D (0.65) | SLC6A4MPOHTR1DHTR1BHTR1A | |
| SCHEMBL8688690 | 0.69 | HTR1D (1.00) | SLC6A4NOS3NOS1NOS2MPO | |
| SCHEMBL7324142 | 0.68 | HTR1A (0.60) | SLC6A4MPOHTR1DHTR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883451-A2 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2008-02-06 | — | — | EP | disclosed |
| WO-2007063418-A2 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2007-06-07 | — | — | WO | disclosed |