Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CCR4 | P51679 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791706 | 0.83 | HRH3 (0.35) | HRH3OPRM1NPY5RSLC6A2SLC6A4 | |
| SCHEMBL4790887 | 0.82 | L3MBTL1 (0.36) | CNR2OPRM1CNR1KCNH2CCR4 | |
| SCHEMBL4790952 | 0.75 | HRH3 (0.42) | HRH3HDAC1HDAC6KCNH2 | |
| SCHEMBL3839546 | 0.74 | KDM4E (0.41) | TP53 | |
| SCHEMBL4169878 | 0.73 | MGLL (0.42) | KCNH2 | |
| SCHEMBL5131548 | 0.73 | HTR2C (0.42) | HRH3SLC6A2SLC6A4 | |
| SCHEMBL5139829 | 0.73 | HTR2C (0.42) | HRH3SLC6A2SLC6A4 | |
| SCHEMBL4167473 | 0.73 | MGLL (0.35) | HDAC1HDAC6SLC6A2SLC6A4 | |
| SCHEMBL4166486 | 0.73 | KDM2B (0.40) | — | |
| SCHEMBL4761940 | 0.73 | HRH3 (0.42) | HRH3HDAC1HDAC6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | claimed |