Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30401692 | 0.96 | ALDH1A1 (0.50) | — | |
| SCHEMBL29497773 | 0.96 | — | — | |
| SCHEMBL29986 | 0.96 | — | — | |
| SCHEMBL607133 | 0.92 | — | — | |
| SCHEMBL8062206 | 0.92 | — | — | |
| SCHEMBL25229785 | 0.92 | — | — | |
| SCHEMBL5679314 | 0.92 | — | — | |
| SCHEMBL8064886 | 0.92 | — | — | |
| SCHEMBL4398787 | 0.92 | — | — | |
| Ammonia Solution, Strong SCHEMBL8128684 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104761561-A | PROCESS FOR REDUCING IMPURITIES IN OXYCODONE BASE | NORAMCO INC | 2015-07-08 | — | — | CN | disclosed |
| WO-2013103841-A1 | METHODS FOR QUANTITATIVE CHIRAL DETERMINATION OF THE d- AND l- ENANTIOMERS OF AMPHETAMINE AND METHAMPHETAMINE | CLINICAL REFERENCE LABORATORY, INC. (US) | 2013-07-11 | — | — | WO | disclosed |
| EP-2121699-B1 | PROCESS FOR PREPARING OXYCODONE HAVING REDUCED LEVELS OF 14-HYDROXYCODEINONE | NORAMCO INC (US) | 2012-09-19 | — | — | EP | disclosed |
| EP-2121698-B1 | PROCESS FOR REDUCING IMPURITIES IN OXYCODONE BASE | NORAMCO INC (US) | 2012-02-01 | — | — | EP | disclosed |
| US-8084579-B2 | Silver halide emulsion for improving photographic products such as photographic paper or cellulose films | FUJI FILM MANUFACTURING EUROPE B.V. (NL) | 2011-12-27 | — | — | US | disclosed |
| US-8058439-B2 | Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone | NORAMCO, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20110144340-A1 | PROCESS FOR PREPARING OXYCODONE HAVING REDUCED LEVELS OF 14- HYDROXYCODEINONE | NORAMCO, LLC (FORMERLY KNOWN AS NORAMCO, INC.) | 2011-06-16 | — | — | US | disclosed |
| US-7906647-B2 | Heating an oxycodone base starting material having more than 100 ppm of 14-hydroxycodeinone and sodium hydrosulfite, sodium bisulfite, or sodium metabisulfite in an alcohol/water; isolating oxycodone base having less than 10 ppm of 14-hydroxycodeinone | NORAMCO, INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-7875719-B2 | Oxidizing thebaine to produce 14-hydroxycodeinone, hydrogenating to produce oxycodone, mixing with n-butanol, basification with sodium hydroxide, isolating purified oxycodone | NORAMCO, LLC (FORMERLY KNOWN AS NORAMCO, INC.) | 2011-01-25 | — | — | US | disclosed |
| EP-2121699-A1 | PROCESS FOR PREPARING OXYCODONE HAVING REDUCED LEVELS OF 14-HYDROXYCODEINONE | NORAMCO, INC. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20040254079-A1 | Composition and Method for Treating a Subterranean Formation | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2004-12-16 | — | — | US | disclosed |
| WO-2004094557-A1 | COMPOSITION AND METHOD FOR TREATING A SUBTERRANEAN FORMATION | SCHLUMBERGER CANADA LIMITED (CA) | 2004-11-04 | — | — | WO | disclosed |
| EP-0926543-B1 | Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof | FUJI PHOTO FILM BV (NL) | 2004-05-12 | — | — | EP | disclosed |
| US-20030229205-A1 | Method for recombinant microorganism expression and isolation of collagen-like polypeptides | FUJI PHOTO FILM B.V. | 2003-12-11 | — | — | US | disclosed |
| US-6150081-A | NUCLEATED WITH PEPTIZER | FUJI PHOTO FILM B.V. (NL) | 2000-11-21 | — | — | US | disclosed |
| EP-0926543-A1 | Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof | Fuji Photo Film B.V. (NL) | 1999-06-30 | — | — | EP | disclosed |
| US-5814226-A | Method of removing heavy metal ions from a liquid with chemically active ceramic compositions with a thiol and/or amine moiety | SYRACUSE UNIVERSITY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5616533-A | Chemically active ceramic compositions with a thiol and/or amine moiety | SYRACUSE UNIVERSITY (US) | 1997-04-01 | — | — | US | disclosed |
| WO-1996009985-A1 | CHEMICALLY ACTIVE CERAMIC COMPOSITIONS WITH A THIOL AND/OR AMINE MOIETY | SYRACUSE UNIVERSITY (US) | 1996-04-04 | — | — | WO | disclosed |
| EP-0083186-A2 | Thiazole derivatives as H2-receptor antagonists | ELI LILLY AND COMPANY (US) | 1983-07-06 | — | — | EP | disclosed |