Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 9/20 | 0.38 |
| ▸ | CTSS | P25774 | 9/20 | 0.38 |
| ▸ | CTSK | P43235 | 7/20 | 0.38 |
| ▸ | VHL | P40337 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023325 | 0.86 | ALDH1A1 (0.49) | AAK1ALDH1A1SMN1; SMN2CTSLCTSS | |
| SCHEMBL4798028 | 0.80 | CTSL (0.38) | AAK1SMN1; SMN2CTSLCTSSCTSK | |
| SCHEMBL4799148 | 0.76 | CTSS (0.44) | AAK1CTSLCTSSCTSKMETAP2 | |
| SCHEMBL4801927 | 0.76 | CTSS (0.41) | CTSLCTSSCTSKCTSCMETAP2 | |
| SCHEMBL4798550 | 0.75 | AAK1 (0.42) | AAK1CTSLCTSSCTSKMETAP2 | |
| SCHEMBL4800048 | 0.75 | CTSD (0.42) | AAK1ALDH1A1CTSLCTSSCTSK | |
| SCHEMBL4797862 | 0.75 | CTSS (0.48) | AAK1CTSLCTSSCTSKMETAP2 | |
| SCHEMBL4798054 | 0.74 | CTSS (0.51) | CTSLCTSSCTSKMETAP2METAP1 | |
| SCHEMBL4798738 | 0.74 | CTSD (0.46) | ALDH1A1SMN1; SMN2CTSLCTSSCTSK | |
| SCHEMBL4796328 | 0.73 | CTSL (0.40) | CTSLCTSSCTSKMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2008-10-02 | — | — | US | claimed |
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2008-10-02 | — | — | US | disclosed |
| US-7384970-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2008-06-10 | — | — | US | disclosed |
| US-20040248887-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-12-09 | — | — | US | disclosed |
| WO-2004084843-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248887-A1 | Inhibitors of cathepsin S | CTSS, CTSB, CTSZ | F2RL1 89/4885AAK1 2822/4885ALDH1A1 3512/4885 |
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | CTSS, CTSB, CTSZ | F2RL1 89/4885AAK1 2822/4885ALDH1A1 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.