SCHEMBL4797063

SCHEMBL4797063

COC(=O)c1cc2c(OC)c(OC)ccc2c2c1C=CC(c1ccccc1)(c1ccccc1)O2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.37
CASP1 P29466 1/20 0.37
CASP7 P55210 1/20 0.37
HIF1A Q16665 8/20 0.36
ALDH1A1 P00352 2/20 0.36
HPGD P15428 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
PKM P14618 1/20 0.35
DHODH Q02127 1/20 0.35
GAA P10253 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
ACLY P53396 1/20 0.34
MAPK1 P28482 1/20 0.34
HSD17B10 Q99714 1/20 0.34
HSP90AA1 P07900 1/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA7 P43166 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4795527 0.95 EIF4A1 (0.37) KDM4ECASP1CASP7HIF1AALDH1A1
SCHEMBL5422759 0.95 NPSR1 (0.35) KDM4ECASP1CASP7HIF1AALDH1A1
SCHEMBL27748008 0.92 HIF1A (0.35) KDM4ECASP1CASP7HIF1APKM
SCHEMBL5435358 0.91 KMT2A (0.37) KDM4ECASP1CASP7HIF1AALDH1A1
SCHEMBL7784037 0.89 MAPT (0.38) KDM4EHIF1AALDH1A1NPSR1GAA
SCHEMBL4795512 0.86 PKM (0.34) KDM4ECASP1CASP7HIF1AALDH1A1
SCHEMBL6131938 0.83 DHODH (0.40) KDM4ECASP1CASP7ALDH1A1HPGD
SCHEMBL1331992 0.81 HIF1A (0.35) KDM4ECASP1CASP7HIF1AALDH1A1
SCHEMBL26290022 0.81 KDM4E (0.45) KDM4EALDH1A1HPGDNPSR1PKM
SCHEMBL4798246 0.80 PLA2G2A (0.41) KDM4ECASP1ALDH1A1HPGDNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101346663-A Photochromic 2H-naphthopyrans TRANSITIONS OPTICAL INC (US) 2009-01-14 CN claimed
EP-1963918-A1 PHOTOCHROMIC 2H-NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2008-09-03 EP claimed
US-20070145337-A1 Photochromic 2H-naphthopyrans TRANSITIONS OPTICAL, INC. 2007-06-28 US claimed
WO-2007073463-A1 PHOTOCHROMIC 2H-NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2007-06-28 WO claimed
CN-101346663-A Photochromic 2H-naphthopyrans TRANSITIONS OPTICAL INC (US) 2009-01-14 CN disclosed
EP-1963918-A1 PHOTOCHROMIC 2H-NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2008-09-03 EP disclosed
US-20070145337-A1 Photochromic 2H-naphthopyrans TRANSITIONS OPTICAL, INC. 2007-06-28 US disclosed
WO-2007073463-A1 PHOTOCHROMIC 2H-NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2007-06-28 WO disclosed