Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4797063 | 0.89 | KDM4E (0.37) | MEN1KMT2AL3MBTL1GAAHIF1A | |
| SCHEMBL7785460 | 0.87 | MAPT (0.39) | MAPTRAB9ANPC1SMN1; SMN2GFER | |
| SCHEMBL5422759 | 0.86 | NPSR1 (0.35) | MAPTSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL4795527 | 0.86 | EIF4A1 (0.37) | KMT2AHIF1AKDM4EALDH1A1 | |
| SCHEMBL14629673 | 0.86 | HIF1A (0.38) | MAPTRAB9ANPC1SMN1; SMN2GFER | |
| SCHEMBL7777302 | 0.85 | DHODH (0.37) | MAPTRAB9ANPC1SMN1; SMN2GFER | |
| SCHEMBL7784131 | 0.85 | MAPT (0.39) | MAPTRAB9ANPC1SMN1; SMN2GFER | |
| SCHEMBL27748008 | 0.83 | HIF1A (0.35) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL5549293 | 0.83 | MAPT (0.39) | MAPTRAB9ANPC1SMN1; SMN2GFER | |
| SCHEMBL5435358 | 0.83 | KMT2A (0.37) | KMT2AL3MBTL1HIF1AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140892-A1 | PHOTOCHROMIC SUBSTIITUTED 2H-NAPHTHO[1,2-B]PYRANS | JAMES ROBINSON LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035902-A1 | PHOTOCHROMIC SUBSTITUTED 2H-NAPHTHO[1,2-b]PYRANS | JAMES ROBINSON LIMITED (GB) | 2000-06-22 | — | — | WO | disclosed |