SCHEMBL4797238

SCHEMBL4797238

Nc1nc(Cl)cc(Cl)c1N

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
CYP3A4 P08684 1/20 0.43
HSP90AB1 P08238 5/20 0.35
HSP90AA1 P07900 4/20 0.35
GAA P10253 1/20 0.35
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34
KDM4E B2RXH2 2/20 0.33
NQO1 P15559 1/20 0.33
KMT2A Q03164 2/20 0.32
POLA1 P09884 1/20 0.32
TDP1 Q9NUW8 2/20 0.32
CDK2 P24941 1/20 0.32
MAPT P10636 1/20 0.31
GLP1R P43220 1/20 0.31
POLB P06746 1/20 0.31
APEX1 P27695 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9476338 0.81 ALDH1A1 (0.46) ALDH1A1CYP3A4HSP90AB1HSP90AA1GAA
SCHEMBL17595014 0.79 ALDH1A1 (0.43) ALDH1A1CYP3A4GAACA1CA2
SCHEMBL19782400 0.75 KDM4E (0.41) ALDH1A1CYP3A4HSP90AB1HSP90AA1KDM4E
SCHEMBL15819694 0.75 CYP3A4 (0.40) ALDH1A1CYP3A4GAAKDM4EKMT2A
SCHEMBL28158622 0.75 HSP90AA1 (0.33) HSP90AB1HSP90AA1GAAKDM4ENQO1
SCHEMBL535658 0.70 ALDH1A1 (0.36) ALDH1A1CYP3A4HSP90AB1HSP90AA1GAA
SCHEMBL14764510 0.70 KDM4E (0.32) ALDH1A1HSP90AA1KDM4EKMT2AMAPT
SCHEMBL4188467 0.70 ALDH1A1 (0.37) ALDH1A1HSP90AB1HSP90AA1KMT2ATDP1
SCHEMBL30313634 0.70 ALDH1A1 (0.37) ALDH1A1HSP90AB1HSP90AA1KMT2ATDP1
SCHEMBL11293369 0.69 POLB (0.43) ALDH1A1GAAKDM4EKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4694893-A1 NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME TME Therapeutics LLC (US) 2026-02-18 EP disclosed
US-20250326748-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC (US) 2025-10-23 US disclosed
US-12428425-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use AMGEN INC. (US) 2025-09-30 US disclosed
WO-2025101780-A1 PHARMACOLOGICAL CORRECTORS OF RHODOPSIN AND USES THEREOF OCTANT, INC. (US) 2025-05-15 WO disclosed
WO-2025080788-A1 CCR4 INHIBITORS AND METHODS OF USE THEREOF RAYTHERA, INC. (US) 2025-04-17 WO disclosed
WO-2024216229-A1 NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME TME THERAPEUTICS LLC (US) 2024-10-17 WO disclosed
US-20240309003-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. (US) 2024-09-19 US disclosed
EP-4412617-A1 NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME TME Therapeutics LLC (US) 2024-08-14 EP disclosed
US-20240182477-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. 2024-06-06 US disclosed
WO-2024057013-A1 NLRP3 MODULATORS EXSCIENTIA AI LIMITED (GB) 2024-03-21 WO disclosed
US-20050090666-A1 Process for producing 2,6-dihalogenopurine SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-04-28 US disclosed
EP-1375502-A1 PROCESS FOR PRODUCING 2,6-DIHALOGENOPURINE SUMIKA FINE CHEMICALS Co., Ltd. (JP) 2004-01-02 EP disclosed
US-20030144508-A1 Process for producing 2,6-dihalogenopurine SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-07-31 US disclosed
EP-0255217-B1 FUSED IMIDAZOHETEROCYCLIC COMPOUNDS A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) 1992-01-22 EP disclosed
US-4948800-A MUSCLE RELAXANTS; ANTICONVULSANTS; ANXIOLYTIC AGENTS; 3-HYDROXYALKYL-PYRIDO(4,5-B OR-C)IMIDAZOLE COMPOUNDS A. H. ROBINS COMPANY, INCORPORATED (US) 1990-08-14 US disclosed
US-4914109-A ANTICONVULSANTS, ANTIANXIETY AGENTS A. H. ROBINS COMPANY, INCORPORATED (US) 1990-04-03 US disclosed
US-4873251-A MUSCLE RELAXANTS, ANTICONVULSANTS, ANTIANXIETY AGENTS A. H. ROBINS COMPANY, INCORPORATED (US) 1989-10-10 US disclosed
US-4824951-A MUSCLE RELAXANTS, ANTICONVULSANTS, ANXIOLYTIC AGENTS A. H. ROBINS COMPANY, INCORPORATED (US) 1989-04-25 US disclosed
US-4772600-A MUSCLE RELAXANTS, ANTICONVULSANTS, ANXIOLYTIC A. H. ROBINS COMPANY, INC. (US) 1988-09-20 US disclosed
EP-0255217-A1 Fused imidazoheterocyclic compounds A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) 1988-02-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12428425-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use MSR1, FPR2, CD14 ALDH1A1 2654/4885CYP3A4 1273/4885HSP90AB1 2919/4885
US-20240309003-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE MSR1, FPR2, CD14 ALDH1A1 2654/4885CYP3A4 1273/4885HSP90AB1 2919/4885
US-20240182477-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE MSR1, FPR2, CD14 ALDH1A1 2654/4885CYP3A4 1273/4885HSP90AB1 2919/4885
US-20250326748-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING RBM17, SNRPA, SNRPA1 ALDH1A1 3559/4885CYP3A4 3937/4885HSP90AB1 1492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.