Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 5/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RHEB | Q15382 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL479998 | 0.91 | ALDH1A1 (0.34) | BRD4ALDH1A1 | |
| SCHEMBL479197 | 0.89 | SCN8A (0.34) | BRD4FFAR1RHEB | |
| SCHEMBL480101 | 0.88 | MCL1 (0.35) | PTGER4PTGER2RXRABRD4MCL1 | |
| SCHEMBL479715 | 0.88 | IGFBP3 (0.35) | PTGER4PTGER2LPAR1LPAR5FFAR1 | |
| SCHEMBL479714 | 0.88 | MRGPRX4 (0.36) | PTGER4PTGER2FFAR1 | |
| SCHEMBL479923 | 0.84 | SCN8A (0.36) | FFAR1 | |
| SCHEMBL479736 | 0.83 | PTGDR2 (0.35) | — | |
| SCHEMBL479879 | 0.82 | ACACB (0.32) | — | |
| SCHEMBL479983 | 0.80 | KDR (0.36) | ALDH1A1 | |
| SCHEMBL479931 | 0.80 | S1PR2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411361-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-02-01 | — | — | EP | claimed |
| WO-2010108902-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-30 | — | — | WO | claimed |
| EP-2411361-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108902-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-30 | — | — | WO | disclosed |