Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 2/20 | 0.34 |
| ▸ | ARG2 | P78540 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 4/20 | 0.33 |
| ▸ | FPR3 | P25089 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654938 | 0.85 | ARG1 (0.45) | ARG1ARG2ALDH1A1HTTMEN1 | |
| SCHEMBL7091788 | 0.85 | ARG1 (0.45) | ARG1ARG2ALDH1A1HTTMEN1 | |
| SCHEMBL14526212 | 0.83 | ADAM17 (0.37) | ARG1ARG2ALDH1A1HTTMEN1 | |
| SCHEMBL4800534 | 0.76 | SLC6A2 (0.42) | MEN1KMT2ASMN1; SMN2CXCR3MME | |
| SCHEMBL14254721 | 0.69 | KMT2A (0.39) | ALDH1A1HTTMEN1KMT2AKDM1A | |
| SCHEMBL4799890 | 0.68 | ARG1 (0.42) | ARG1ARG2HTTGAA | |
| SCHEMBL4800313 | 0.64 | HRH3 (0.43) | FPR2FPR3MEN1KMT2APOLB | |
| SCHEMBL17478588 | 0.63 | MAPT (0.38) | ALDH1A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL14254704 | 0.62 | FPR2 (0.44) | ALDH1A1FPR2MEN1KMT2APOLB | |
| SCHEMBL4847242 | 0.62 | SLC6A2 (0.40) | ALDH1A1HTTFPR2SMN1; SMN2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375237-B2 | Pyrrolizine compounds useful as anti-inflammatory agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-20 | — | — | US | disclosed |
| US-20060052434-A1 | Pyrrolizine compounds useful as anti-inflammatory agents | CEREP S.A. (FR) | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052434-A1 | Pyrrolizine compounds useful as anti-inflammatory agents | NFKBIA, TNF, NFKB1 | ARG1 6/4885ARG2 54/4885ALDH1A1 2590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.