Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 2/20 | 0.45 |
| ▸ | ARG2 | P78540 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7091788 | 1.00 | ARG1 (0.45) | ARG1ARG2KDM1ARCOR1ALDH1A1 | |
| SCHEMBL4802125 | 0.85 | ARG1 (0.34) | ARG1ARG2KDM1ARCOR1ALDH1A1 | |
| SCHEMBL14526212 | 0.84 | ADAM17 (0.37) | ARG1ARG2ALDH1A1HTTPOLB | |
| SCHEMBL4799890 | 0.82 | ARG1 (0.42) | ARG1ARG2HTT | |
| SCHEMBL4849081 | 0.74 | SLC6A2 (0.44) | ARG1ARG2MMENPC1HPGD | |
| SCHEMBL1816048 | 0.74 | SLC6A2 (0.44) | ARG1ARG2MMENPC1HPGD | |
| SCHEMBL27482371 | 0.69 | MME (0.36) | ARG1ARG2ALDH1A1MMEPOLB | |
| SCHEMBL6523 | 0.66 | MME (0.40) | ALDH1A1MMEMAPTMEN1KMT2A | |
| SCHEMBL6659083 | 0.66 | FAAH (0.47) | ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL7440413 | 0.66 | ALDH1A1 (0.41) | ALDH1A1MAPTMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199125-B2 | Spiro-cyclic compounds useful as anti-inflammatory agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-03 | — | — | US | disclosed |
| US-20050119279-A1 | Spiro-cyclic compounds useful as anti-inflammatory agents | CEREP SA (FR) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119279-A1 | Spiro-cyclic compounds useful as anti-inflammatory agents | CCR9, MSR1, CCR3 | ARG1 330/4885ARG2 1047/4885KDM1A 2047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.