Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MMP12 | P39900 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | UQCRB | P14927 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 8/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 5/20 | 0.50 |
| ▸ | MMP13 | P45452 | 4/20 | 0.50 |
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56650 | 0.86 | CA1 (0.58) | MMP1CA1CA2CA12CA9 | |
| Hydrochloric Acid SCHEMBL21326160 | 0.84 | CA1 (0.56) | MMP1CA1CA2MEN1KMT2A | |
| SCHEMBL13485822 | 0.80 | MMP2 (0.78) | MMP1GAAMMP12CA1CA2 | |
| SCHEMBL3906959 | 0.78 | NR3C2 (0.61) | MMP1GAAMMP12CA1CA2 | |
| SCHEMBL10780756 | 0.78 | MMP1 (0.55) | MMP1GAAMMP12CA1CA2 | |
| SCHEMBL417467 | 0.78 | CA1 (0.59) | MMP1GAAMMP12CA1CA2 | |
| Benzene SCHEMBL29215798 | 0.78 | KMT2A (0.60) | MMP1CA1CA2CA12CA9 | |
| SCHEMBL1068742 | 0.78 | MMP1 (0.50) | MMP1GAAMMP12CA1CA2 | |
| SCHEMBL5857917 | 0.77 | MMP2 (0.54) | MMP1GAAMMP12CA1CA2 | |
| Benzenesulfonamide SCHEMBL29068266 | 0.77 | CA1 (0.67) | MMP1CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7381728-B2 | Piperazine derivatives useful for the treatment of gastrointestinal disorders | GLAXO GROUP LIMITED (GB) | 2008-06-03 | — | — | US | disclosed |
| US-20070259877-A1 | Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders | GLAXO GROUP LIMITED | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259877-A1 | Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders | GHSR, GHRHR, GIPR | MMP1 3333/4885GAA 1116/4885MMP12 3659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.