Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4806501 | 0.81 | L3MBTL1 (0.36) | RAB9AL3MBTL1KDM4EHSP90AA1GAA | |
| SCHEMBL5196628 | 0.79 | — | — | |
| SCHEMBL16642010 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL4805933 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL4806230 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL5228882 | 0.76 | NPC1 (0.31) | RAB9AL3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL4808159 | 0.76 | MAPT (0.37) | RAB9AL3MBTL1NPC1KDM4EHSP90AA1 | |
| Hydrochloric Acid SCHEMBL4807994 | 0.76 | NPC1 (0.31) | RAB9AL3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL4805175 | 0.74 | NPC1 (0.34) | RAB9AL3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL4913610 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7399320-B2 | Use of tetra-azapentamethine compounds as direct dyeing agents and novel tetra-azapentamethine compounds | L'OREAL (FR) | 2008-07-15 | — | — | US | claimed |
| US-20080092307-A1 | Use of tetra-azapentamethine compounds as direct dyeing agents and novel tetra-azapentamethine compounds | L'OREAL (FR) | 2008-04-24 | — | — | US | claimed |
| EP-1548006-B1 | Synthesis of tetraazapentamethine derivatives, keratin fibers dyeing process which uses such synthesis | OREAL (FR) | 2007-09-05 | — | — | EP | claimed |
| WO-2007071689-A1 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE AND ANOTHER PARTICULAR DIRECT DYE | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | claimed |
| WO-2007071685-A1 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE AND ANOTHER PARTICULAR DIRECT DYE | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | claimed |
| WO-2007071688-A1 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, A PARTICULAR OXIDATION BASE AND A COUPLER | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | claimed |
| WO-2007071686-A1 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, AN OXIDATION BASE AND A PARTICULAR COUPLER | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | claimed |
| WO-2007071684-A2 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE AND AN AMINO SILICONE | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | claimed |
| WO-2007071683-A1 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE AND A NONIONIC SURFACTANT | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | claimed |
| US-20050198744-A1 | Applying 2-[5-(N-methyl-2-pyridinylidene)-1-formazano]-N-methylpyridinium chloride and an oxidizing agent, developing the desired coloration | L'OREAL S.A. (FR) | 2005-09-15 | — | — | US | claimed |
| US-20050028300-A1 | Use of tetra-azapentamethine compounds as direct dyeing agents and novel tetraazapentamethine compounds | L'OREAL (FR) | 2005-02-10 | — | — | US | claimed |
| US-7399320-B2 | Use of tetra-azapentamethine compounds as direct dyeing agents and novel tetra-azapentamethine compounds | L'OREAL (FR) | 2008-07-15 | — | — | US | disclosed |
| US-20080092307-A1 | Use of tetra-azapentamethine compounds as direct dyeing agents and novel tetra-azapentamethine compounds | L'OREAL (FR) | 2008-04-24 | — | — | US | disclosed |
| US-7311736-B2 | Use of tetra-azapentamethine compounds as direct dyeing agents and novel tetra-azapentamethine compounds | L'OREAL (FR) | 2007-12-25 | — | — | US | disclosed |
| US-7288120-B2 | Synthesis of tetraazapentamethine compounds, and processes for dyeing keratin fibers using this synthesis | L'OREAL S.A. (FR) | 2007-10-30 | — | — | US | disclosed |
| WO-2007071686-A1 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, AN OXIDATION BASE AND A PARTICULAR COUPLER | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007071689-A1 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE AND ANOTHER PARTICULAR DIRECT DYE | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007071688-A1 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, A PARTICULAR OXIDATION BASE AND A COUPLER | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | disclosed |
| US-20050198744-A1 | Applying 2-[5-(N-methyl-2-pyridinylidene)-1-formazano]-N-methylpyridinium chloride and an oxidizing agent, developing the desired coloration | L'OREAL S.A. (FR) | 2005-09-15 | — | — | US | disclosed |
| US-20050028300-A1 | Use of tetra-azapentamethine compounds as direct dyeing agents and novel tetraazapentamethine compounds | L'OREAL (FR) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050028300-A1 | Use of tetra-azapentamethine compounds as direct dyeing agents and novel tetraazapentamethine compounds | KRT18, TET1, DNMT1 | RAB9A 3479/4885L3MBTL1 4824/4885NPC1 4628/4885 |
| US-20050198744-A1 | Applying 2-[5-(N-methyl-2-pyridinylidene)-1-formazano]-N-methylpyridinium chloride and an oxidizing agent, developing the desired coloration | KRT18, TPM4, AZI2 | RAB9A 4047/4885L3MBTL1 4434/4885NPC1 4861/4885 |
| US-20080092307-A1 | Use of tetra-azapentamethine compounds as direct dyeing agents and novel tetra-azapentamethine compounds | KRT18, TUBA4A, TUBB4A | RAB9A 3045/4885L3MBTL1 4825/4885NPC1 4393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.