⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL27754830 | 0.92 | CA2 (0.36) | — | |
| Naphthalene SCHEMBL7850037 | 0.90 | LMNA (0.41) | — | |
| Biphenyl SCHEMBL5706278 | 0.88 | CA2 (0.47) | — | |
| SCHEMBL329815 | 0.78 | — | — | |
| SCHEMBL1259248 | 0.76 | — | — | |
| SCHEMBL29207412 | 0.74 | TSHR (0.31) | — | |
| SCHEMBL3177230 | 0.71 | ALDH1A1 (0.35) | — | |
| SCHEMBL11004258 | 0.70 | MEN1 (0.35) | — | |
| SCHEMBL6403890 | 0.70 | HTR6 (0.50) | — | |
| Acetic Acid SCHEMBL28527454 | 0.69 | RAB9A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120157627-A | Isoxazole sulfonamide derivative compound and preparation method and application thereof | 东北农业大学 | 2025-06-17 | — | — | CN | claimed |
| CN-113651766-B | Isoxazole sulfonamide compound with BRD4 inhibitory activity, and preparation method and application thereof | 泰州职业技术学院 | 2023-08-18 | — | — | CN | claimed |
| CN-113651766-A | Isoxazole sulfonamide compound with BRD4 inhibitory activity and preparation method and application thereof | 泰州职业技术学院 | 2021-11-16 | — | — | CN | claimed |
| EP-3600296-A1 | NOVEL COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INSULIN RESISTANCE | Université Paris Diderot (FR) | 2020-02-05 | — | — | EP | claimed |
| EP-0699191-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027979-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | IMMUNOPHARMACEUTICS, INC. (US) | 1994-12-08 | — | — | WO | claimed |
| CN-120157627-A | Isoxazole sulfonamide derivative compound and preparation method and application thereof | 东北农业大学 | 2025-06-17 | — | — | CN | disclosed |
| CN-120157627-A | Isoxazole sulfonamide derivative compound and preparation method and application thereof | 东北农业大学 | 2025-06-17 | — | — | CN | disclosed |
| CN-120157627-A | Isoxazole sulfonamide derivative compound and preparation method and application thereof | 东北农业大学 | 2025-06-17 | — | — | CN | disclosed |
| EP-4558497-A1 | NOVEL ISOTHIAZOL-3-YL AND ISOXAZOL-3-YL SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2025-05-28 | — | — | EP | disclosed |
| CN-113227131-B | Modified antibody Fc and methods of use thereof | 豪夫迈·罗氏有限公司 | 2025-03-04 | — | — | CN | disclosed |
| WO-2024017855-A1 | NOVEL ISOTHIAZOL-3-YL AND ISOXAZOL-3-YL SULFONAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |
| WO-2024017855-A1 | NOVEL ISOTHIAZOL-3-YL AND ISOXAZOL-3-YL SULFONAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |
| WO-1997038986-A1 | SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES AS PRODRUGS OF COX-2 INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-23 | — | — | WO | disclosed |
| CN-1143639-A | Oxime derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1997-02-26 | — | — | CN | disclosed |
| US-5571821-A | CARDIOVASCULAR DISORDERS TO MODULATE ENDOTHELIN, HYPOTENSIVE AGENTS AND VASOCONSTRICTION | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0702012-A1 | Substituted isoxazole sulfonamides and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-20 | — | — | EP | disclosed |
| EP-0699191-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027979-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | IMMUNOPHARMACEUTICS, INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| EP-0234352-B1 | SULFONAMIDE COMPOUNDS AND SALTS THEREOF, HERBICIDAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR PRODUCING THEM | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1992-04-29 | — | — | EP | disclosed |