Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | MITF | O75030 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4805173 | 0.89 | HDAC1 (0.53) | NPC1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL4801474 | 0.88 | HDAC1 (0.55) | NPC1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL4807423 | 0.85 | HDAC1 (0.51) | HTTSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL7509832 | 0.84 | HTT (0.56) | HTTNPSR1MAPK1NPC1MITF | |
| SCHEMBL4801436 | 0.84 | MAPT (0.50) | HTTNPC1SMN1; SMN2MAPTLMNA | |
| SCHEMBL4807419 | 0.82 | HDAC1 (0.49) | HTTSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL4812192 | 0.81 | LMNA (0.51) | HTTNPC1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL13754013 | 0.77 | KDM4E (0.51) | HTTNPSR1MAPK1NPC1MITF | |
| SCHEMBL4812181 | 0.76 | ALDH1A1 (0.49) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL1285789 | 0.76 | VCAM1 (0.74) | HTTNPSR1MAPK1NPC1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427260-B2 | Efficient methods for solid phase synthesis using trityl chloride resins | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-09-23 | — | — | US | disclosed |
| US-20040096904-A1 | Efficient methods for solid phase synthesis using trityl chloride resins | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2004-05-20 | — | — | US | disclosed |
| WO-2002079278-A1 | EFFICIENT METHODS FOR SOLID PHASE SYNTHESIS USING TRITYL CHLORIDE RESINS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2002-10-10 | — | — | WO | disclosed |